Trombofilie v těhotenství – fyziologie a patofyziologie hemokoagulačních změn v normální graviditě a při některých patologických těhotenských stavech

Thromboembolism in Pregnancy – Physiology and Pathophysiology of Hemocoagulation Changes During Normal and Pathological Gravidity

Venous thromboembolism belongs to most feared complications in pregnancy. It is the leading cause of illness and even death during pregnancy and puerperium. Thrombophilias - acquired or inherited, manifest often during pregnancy and puerperium. These risk states could endanger normal pregnancy by increasing the probability of the first or recurrent thromboembolic incident and adverse obstetric events (pregnancy loss, pre-eclampsia, intrauterine growth restriction, placental abruption). 

Key words:
pregnancy, haemostasis, thrombosis, thrombophilia, pre-eclampsia.