1. Urbanová K., Koťová M., Vaňková Z. The incidence of cleft lip and palate in the Czech Republic in 1994–2008. Bratisl Lek Listy. 2013, 114 (8): 474–479.
2. Urbanová K., Koťová M., Langová K. Cleft lip and palate patients’ quality of life. Ortodoncie. 2024, 33 (3): 144–156.
3. Hammond NL., Dixon MJ. Revisiting the embryogenesis of lip and palate development. Oral Diseases. 2022, 28 (5): 1306–1326.
4. Dixon MJ., Marazita ML., Beaty TH., et al. Cleft lip and palate: understanding genetic and environmental influences. Nat Rev Genet. 2011, 12 (3): 167–178.
5. Boyles AL., DeRoo LA., Lie RT., et al. Maternal alcohol consumption, alcohol metabolism genes, and the risk of oral clefts. Am J Epidemiol. 2010, 172 (8): 924–931.
6. Zeiger JS., Beaty TH., Liang KY. Oral clefts, maternal smoking, and TGFA: a meta-analysis. Cleft Palate Craniofac J. 2005, 42 (1): 58–63.
7. Kutbi H., Wehby GL., Moreno Uribe LM., et al. Maternal underweight and obesity and risk of orofacial clefts. Int J Epidemiol. 2017, 46 (1): 190–199.
8. Kozma A. Gestational diabetes mellitus and the development of cleft lip/palate in newborns. Acta Endocrinol. 2019, 15 (1): 118–122.
9. Sharp GC., Stergiakouli E., Sandy J., et al. Epigenetics and orofacial clefts: a brief introduction. Cleft Palate Craniofac J. 2018, 55 (6): 795–797.
10. Brăila AD., Damian CM., Albu CC., et al. Prenatal diagnosis of cleft lip and palate: a retrospective study. J Clin Med. 2024, 13 (16): 4804.
11. Maarse W., Pistorius LR., van Eeten WK., et al. Prenatal ultrasound screening for orofacial clefts. Ultrasound Obstet Gynecol. 2011, 38 (4): 434–439.
12. Martinez-Ten P., Adiego B., Illescas T., et al. First-trimester diagnosis of cleft lip and palate using three-dimensional ultrasound. Ultrasound Obstet Gynecol. 2012, 40 (1): 40–46.
13. James O., Erinoso OA., Ogunlewe AO., et al. Parental age and the risk of cleft lip and palate in a Nigerian population: a case-control study. Ann Maxillofac Surg. 2020, 10 (2): 429–433.
14. Malic CC., Lam M., Donelle J., et al. Incidence, risk factors, and mortality associated with orofacial cleft among children in Ontario, Canada. JAMA Netw Open. 2020, 3 (2): e1921036.
15. Guichoud Y., El Ezzi O., de Buys Roessingh A. Cleft lip and palate antenatal diagnosis: a Swiss university center performance analysis. Diagnostics. 2023, 13 (15): 2479.
16. Bille C., Skytthe A., Vach W., et al. Parent’s age and the risk of oral clefts. Epidemiology. 2005, 16 (3): 311–316.
17. Hermann NV., Darvann TA., Munch A., et al. Parental age in relation to the severity of cleft lip and/or palate. Orthod Craniofac Res. 2018, 21 (4): 236–241.
18. Berg E., Lie RT., Sivertsen Å., et al. Parental age and the risk of isolated cleft lip: a registry-based study. Ann Epidemiol. 2015, 25 (12): 942–947.e1.
19. Český statistický úřad. Porodnost a plodnost 2011–2021. 2022 [online]. Available from: https: //csu.gov.cz/produkty/porodnost-a-plod - nost-2011-2021.
20. Vetešková M. Věk rodičů dětí narozených v Jihomoravském kraji v roce 2023. 2024 [online]. Available from: https: //csu.gov.cz/jhm/vek-rodicu-deti-narozenych-v-jihomoravskem-kraji-v-roce-2023.
21. Rankin J., Tennant PWG., Stothard KJ., et al. Maternal body mass index and congenital anomaly risk: a cohort study. Int J Obes. 2010, 34 (9): 1371–1380.
22. Blanco R., Colombo A., Suazo J. Maternal obesity is a risk factor for orofacial clefts: a meta-analysis. Br J Oral Maxillofac Surg. 2015, 53 (8): 699–704.
23. Wehby GL., Uribe LM., Wilcox AJ., et al. Interaction between smoking and body mass index and risk of oral clefts. Ann Epidemiol. 2017, 27 (2): 103–107.e2.
24. Carmichael SL., Yang W., Herring A., et al. Maternal food insecurity is associated with increased risk of certain birth defects. J Nutr. 2007, 137 (9): 2087–2092.
25. Mezzasalma L., Santoro M., Coi A., et al. Association between maternal body mass index and congenital anomalies: a case-control study in Tuscany (Italy). Birth Defects Res. 2022, 114 (3–4): 116–123.
26. Stothard KJ., Tennant PWG., Bell R., et al. Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA. 2009, 301 (6): 636–650.
27. Garland MA., Sun B., Zhang S., et al. Role of epigenetics and miRNAs in orofacial clefts. Birth Defects Res. 2020, 112 (19): 1635–1659.
28. Molina-Solana R., Yáñez-Vico RM., Iglesias-Linares A., et al. Current concepts on the effect of environmental factors on cleft lip and palate. Int J Oral Maxillofac Surg. 2013, 42 (2): 177–184.
29. Sabbagh HJ., Zeinalddin M., Al-Batayneh OB., et al. Cleft lip and palate and periconception COVID-19 infection in five Arab countries. Clin Oral Investig. 2024, 28 (11): 586.
30. Mahapure KS., Powar RS. Could maternal stress be a causal factor for nonsyndromic cleft lip and/or palate: a retrospective study. Natl J Maxillofac Surg. 2022, 13 (Suppl 1): S36–S40.
31. Talal AlSharif M., Abdullah Alamoudi R., Jafar Sabbagh H. Maternal stress as a risk factor for non-syndromic orofacial clefts: systematic review and meta-analysis. Saudi Dent J. 2023, 35 (3): 207–219.
32. Wilcox AJ., Lie RT., Solvoll K., et al. Folic acid supplements and risk of facial clefts: national population based case-control study. BMJ. 2007, 334 (7591): 464.
33. Jayarajan R., Natarajan A., Nagamuttu R. Efficacy of periconceptional high-dose folic acid in isolated orofacial cleft prevention: a systematic review. Indian J Plast Surg. 2019, 52 (2): 153–159.
Olga Košková, MD, PhD
Department of Burns and Plastic Surgery
University Hospital Brno
Jihlavská 20, 62500 Brno
Czech Republic
koskova.olga@gmail.com, koskova.olga@fnbrno.cz
Submitted: 18. 5. 2025
Accepted: 5. 7. 2025