Amyotrophic Lateral Sclerosis, A Motoneuron Disorder

Souhrn

The term „motoneuron disorder“ has been used for a degenerative disease of the motor system. In its etiology,the role is probably played by more factors out of which excitotoxic theory has been nowadays consideredas the most significant one. Besides amyotrophic lateral sclerosis, this group also involves progressivebulbar paralysis, progressive muscular atrophy, primary lateral sclerosis, brachial amyotrophic diplegia,and monomelic muscular atrophy. Both clinical and electrophysiological diagnostic criteria have been developedfor ALS, they enable the decision for early therapy as well as inclusion in clinical trials. In addition toriluzole treatment, individual symptomatic therapy is needed.

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