PLOS Genetics - Číslo 6/2020

Perspective

1008714
Osteocalcin promotes bone mineralization but is not a hormone

Stavros C. Manolagas


Formal Comment

1008938
The facts of the matter: What is a hormone?

Gerard Karsenty

1008939
Lack of reproducibility in osteocalcin-deficient mice

Takeshi Moriishi, Toshihisa Komori

1008940
Independent validation of experimental results requires timely and unrestricted access to animal models and reagents

Cassandra R. Diegel, Steven Hann, Ugur M. Ayturk, Jennifer C. W. Hu, Kyung-eun Lim, Casey J. Droscha, Zachary B. Madaj, Gabrielle E. Foxa, Isaac Izaguirre, , Alexander G. Robling, Matthew L. Warman, Bart O. Williams


Research Article

1008312
Nitric oxide mediates neuro-glial interaction that shapes Drosophila circadian behavior

Anatoly Kozlov, Rafael Koch, Emi Nagoshi

1008471
Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses

Melvyn W. Yap, George R. Young, Renata Varnaite, Serge Morand, Jonathan P. Stoye

1008511
JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage

Jérémie Fages, Catherine Chailleux, Jonathan Humbert, Suk-Min Jang, Jérémy Loehr, Jean-Philippe Lambert, Jacques Côté, Didier Trouche, Yvan Canitrot

1008595
Super-resolution imaging of RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic prophase

Johan A. Slotman, Maarten W. Paul, Fabrizia Carofiglio, H. Martijn de Gruiter, Tessa Vergroesen, Lieke Koornneef, Wiggert A. van Cappellen, Adriaan B. Houtsmuller, Willy M. Baarends

1008601
Steroid hormones regulate genome-wide epigenetic programming and gene transcription in human endometrial cells with marked aberrancies in endometriosis

Sahar Houshdaran, Ashwini B. Oke, Jennifer C. Fung, Kim Chi Vo, Camran Nezhat, Linda C. Giudice

1008622
Regulation of olfactory-based sex behaviors in the silkworm by genes in the sex-determination cascade

Jun Xu, Wei Liu, Dehong Yang, Shuqing Chen, Kai Chen, Zulian Liu, Xu Yang, Jing Meng, Guanheng Zhu, Shuanglin Dong, Yong Zhang, Shuai Zhan, Guirong Wang, Yongping Huang

1008715
A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5

Chalita Washington, Rachel Chernet, Rewatee H. Gokhale, Yesenia Martino-Cortez, Hsiu-Yu Liu, Ashley M. Rosenberg, Sivan Shahar, Cathie M. Pfleger

1008717
Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networks

Carmen Santa-Cruz Mateos, Andrea Valencia-Expósito, Isabel M. Palacios, María D. Martín-Bermudo

1008725
Age-of-onset information helps identify 76 genetic variants associated with allergic disease

Manuel A. R. Ferreira, Judith M. Vonk, Hansjörg Baurecht, Ingo Marenholz, Chao Tian, Joshua D. Hoffman, Quinta Helmer, Annika Tillander, Vilhelmina Ullemar, Yi Lu, Sarah Grosche, Franz Rüschendorf, Raquel Granell, Ben M. Brumpton, Lars G. Fritsche, Laxmi Bhatta, Maiken E. Gabrielsen, Jonas B. Nielsen, Wei Zhou, Kristian Hveem, Arnulf Langhammer, Oddgeir L. Holmen, Mari Løset, Gonçalo R. Abecasis, Cristen J. Willer, Nima C. Emami, Taylor B. Cavazos, John S. Witte, Agnieszka Szwajda, , , David A. Hinds, Norbert Hübner, Stephan Weidinger, Patrik KE Magnusson, Eric Jorgenson, Robert Karlsson, Lavinia Paternoster, Dorret I. Boomsma, Catarina Almqvist, Young-Ae Lee, Gerard H. Koppelman

1008740
Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism

Diana C. Odermatt, Wei Ting C. Lee, Sebastian Wild, Stanislaw K. Jozwiakowski, Eli Rothenberg, Kerstin Gari

1008756
NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure

Patrick J. Murphy, Jingtao Guo, Timothy G. Jenkins, Emma R. James, John R. Hoidal, Thomas Huecksteadt, Dallin S. Broberg, James M. Hotaling, David F. Alonso, Douglas T. Carrell, Bradley R. Cairns, Kenneth I. Aston

1008774
Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves

Masanari Takamiya, Johannes Stegmaier, Andrei Yu Kobitski, Benjamin Schott, Benjamin D. Weger, Dimitra Margariti, Angel R. Cereceda Delgado, Victor Gourain, Tim Scherr, Lixin Yang, Sebastian Sorge, Jens C. Otte, Volker Hartmann, Jos van Wezel, Rainer Stotzka, Thomas Reinhard, Günther Schlunck, Thomas Dickmeis, Sepand Rastegar, Ralf Mikut, Gerd Ulrich Nienhaus, Uwe Strähle

1008775
Transcriptomic stratification of late-onset Alzheimer's cases reveals novel genetic modifiers of disease pathology

Nikhil Milind, Christoph Preuss, Annat Haber, Guruprasad Ananda, Shubhabrata Mukherjee, Cai John, Sarah Shapley, Benjamin A. Logsdon, Paul K. Crane, Gregory W. Carter

1008778
Alpha- and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations

Alyson Sujkowski, Anna Gretzinger, Nicolette Soave, Sokol V. Todi, Robert Wessells

1008788
Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease

Liselotte Bäckdahl, Mike Aoun, Ulrika Norin, Rikard Holmdahl

1008790
Exclusive breastfeeding can attenuate body-mass-index increase among genetically susceptible children: A longitudinal study from the ALSPAC cohort

Yanyan Wu, Stephen Lye, Cindy-Lee Dennis, Laurent Briollais

1008792
Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development

Tanzeen Yusuff, Matthew Jensen, Sneha Yennawar, Lucilla Pizzo, Siddharth Karthikeyan, Dagny J. Gould, Avik Sarker, Erika Gedvilaite, Yurika Matsui, Janani Iyer, Zhi-Chun Lai, Santhosh Girirajan

1008799
BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1

Shu Wu, Yuanlong Ge, Xiaocui Li, Yiding Yang, Haoxian Zhou, Kaixuan Lin, Zepeng Zhang, Yong Zhao

1008803
MYO5B mutations in pheochromocytoma/paraganglioma promote cancer progression

Tajana Tešan Tomić, Josefin Olausson, Anna Rehammar, Lily Deland, Andreas Muth, Katarina Ejeskär, Staffan Nilsson, Erik Kristiansson, Ola Nilsson Wassén, Frida Abel

1008805
Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass

Madison L. Doolittle, Gina M. Calabrese, Larry D. Mesner, Dana A. Godfrey, Robert D. Maynard, Cheryl L. Ackert-Bicknell, Charles R. Farber

1008808
In vivo modeling of metastatic human high-grade serous ovarian cancer in mice

Olga Kim, Eun Young Park, David L. Klinkebiel, Svetlana D. Pack, Yong-Hyun Shin, Zied Abdullaev, Robert E. Emerson, Donna M. Coffey, Sun Young Kwon, Chad J. Creighton, Sanghoon Kwon, Edmund C. Chang, Theodore Chiang, Alexander N. Yatsenko, Jeremy Chien, Dong-Joo Cheon, Yang Yang-Hartwich, Harikrishna Nakshatri, Kenneth P. Nephew, Richard R. Behringer, Facundo M. Fernández, Chi-Heum Cho, Barbara Vanderhyden, Ronny Drapkin, Robert C. Bast, Jr, Kathy D. Miller, Adam R. Karpf, Jaeyeon Kim

1008810
GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation

Anbarasi Kothandapani, Samantha R. Lewis, Jessica L. Noel, Abbey Zacharski, Kyle Krellwitz, Anna Baines, Stephanie Winske, Chad M. Vezina, Elena M. Kaftanovskaya, Alexander I. Agoulnik, Emily M. Merton, Martin J. Cohn, Joan S. Jorgensen

1008814
The role of ROC75 as a daytime component of the circadian oscillator in Chlamydomonas reinhardtii

Takuya Matsuo, Takahiro Iida, Ayumi Ohmura, Malavika Gururaj, Daisaku Kato, Risa Mutoh, Kunio Ihara, Masahiro Ishiura

1008822
An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene conversion and transposons

Gareth D. Weedall, Jacob M. Riveron, Jack Hearn, Helen Irving, Colince Kamdem, Caroline Fouet, Bradley J. White, Charles S. Wondji

1008829
BK channel density is regulated by endoplasmic reticulum associated degradation and influenced by the SKN-1A/NRF1 transcription factor

Timothy P. Cheung, Jun-Yong Choe, Janet E. Richmond, Hongkyun Kim

1008830
Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3′UTR intron-containing NMD targets

Pooja Gangras, Thomas L. Gallagher, Michael A. Parthun, Zhongxia Yi, Robert D. Patton, Kiel T. Tietz, Natalie C. Deans, Ralf Bundschuh, Sharon L. Amacher, Guramrit Singh

1008831
Behavioral and brain- transcriptomic synchronization between the two opponents of a fighting pair of the fish Betta splendens

Trieu-Duc Vu, Yuki Iwasaki, Shuji Shigenobu, Akiko Maruko, Kenshiro Oshima, Erica Iioka, Chao-Li Huang, Takashi Abe, Satoshi Tamaki, Yi-Wen Lin, Chih-Kuan Chen, Mei-Yeh Lu, Masaru Hojo, Hao-Ven Wang, Shun-Fen Tzeng, Hao-Jen Huang, Akio Kanai, Takashi Gojobori, Tzen-Yuh Chiang, H. Sunny Sun, Wen-Hsiung Li, Norihiro Okada

1008836
Adaptation of codon usage to tRNA I34 modification controls translation kinetics and proteome landscape

Xueliang Lyu, Qian Yang, Lin Li, Yunkun Dang, Zhipeng Zhou, She Chen, Yi Liu

1008837
Control of mRNA translation by dynamic ribosome modification

Lucia Grenga, Richard Howard Little, Govind Chandra, Stuart Daniel Woodcock, Gerhard Saalbach, Richard James Morris, Jacob George Malone

1008838
ROS regulation of RAS and vulva development in Caenorhabditis elegans

Maximilian Kramer-Drauberg, Ju-Ling Liu, David Desjardins, Ying Wang, Robyn Branicky, Siegfried Hekimi

1008840
The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae

Emma B. Alme, Erica Stevenson, Nevan J. Krogan, Danielle L. Swaney, David P. Toczyski

1008841
yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development

Bernardo Blanco-Sánchez, Aurélie Clément, Sara J. Stednitz, Jennifer Kyle, Judy L. Peirce, Marcie McFadden, Jeremy Wegner, Jennifer B. Phillips, Ellen Macnamara, Yan Huang, David R. Adams, Camilo Toro, William A. Gahl, May Christine V. Malicdan, Cynthia J. Tifft, Erika M. Zink, Kent J. Bloodsworth, Kelly G. Stratton, , David M. Koeller, Thomas O. Metz, Philip Washbourne, Monte Westerfield

1008847
Overlapping functions and protein-protein interactions of LRR-extensins in Arabidopsis

Aline Herger, Shibu Gupta, Gabor Kadler, Christina Maria Franck, Aurélien Boisson-Dernier, Christoph Ringli

1008848
Elevated exopolysaccharide levels in Pseudomonas aeruginosa flagellar mutants have implications for biofilm growth and chronic infections

Joe J. Harrison, Henrik Almblad, Yasuhiko Irie, Daniel J. Wolter, Heather C. Eggleston, Trevor E. Randall, Jacob O. Kitzman, Bethany Stackhouse, Julia C. Emerson, Sharon Mcnamara, Tyler J. Larsen, Jay Shendure, Lucas R. Hoffman, Daniel J. Wozniak, Matthew R. Parsek

1008849
The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants

Hongkuan Wang, Wanyue Xu, Yujin Sun, Qichao Lian, Cong Wang, Chaoyi Yu, Chengpeng He, Jun Wang, Hong Ma, Gregory P. Copenhaver, Yingxiang Wang

1008850
Evolution of Salmonella enterica serotype Typhimurium driven by anthropogenic selection and niche adaptation

Matt Bawn, Nabil-Fareed Alikhan, Gaëtan Thilliez, Mark Kirkwood, Nicole E. Wheeler, Liljana Petrovska, Timothy J. Dallman, Evelien M. Adriaenssens, Neil Hall, Robert A. Kingsley

1008855
Estimation of non-null SNP effect size distributions enables the detection of enriched genes underlying complex traits

Wei Cheng, Sohini Ramachandran, Lorin Crawford

1008861
Adaptive evolution among cytoplasmic piRNA proteins leads to decreased genomic auto-immunity

Luyang Wang, Daniel A. Barbash, Erin S. Kelleher

1008862
A Bayesian method to estimate variant-induced disease penetrance

Brett M. Kroncke, Derek K. Smith, Yi Zuo, Andrew M. Glazer, Dan M. Roden, Jeffrey D. Blume

1008863
NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways

Zhentao Sheng, Wei Du

1008864
­­­­­­Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods

Samuel H. Lewis, Laura Ross, Stevie A. Bain, Eleni Pahita, Steven A. Smith, Richard Cordaux, Eric A. Miska, Boris Lenhard, Francis M. Jiggins, Peter Sarkies, Stephen A. Smith

1008865
Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae

Koji Kasahara, Risa Nakayama, Yuh Shiwa, Yu Kanesaki, Taichiro Ishige, Hirofumi Yoshikawa, Tetsuro Kokubo

1008866
Phylogenetic background and habitat drive the genetic diversification of Escherichia coli

Marie Touchon, Amandine Perrin, Jorge André Moura de Sousa, Belinda Vangchhia, Samantha Burn, Claire L. O’Brien, Erick Denamur, David Gordon, Eduardo PC Rocha

1008867
VolcanoFinder: Genomic scans for adaptive introgression

Derek Setter, Sylvain Mousset, Xiaoheng Cheng, Rasmus Nielsen, Michael DeGiorgio, Joachim Hermisson

1008868
Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson’s disease through mitochondrial dysfunction

Chung-Yang Kao, Mafei Xu, Leiming Wang, Shih-Chieh Lin, Hui-Ju Lee, Lita Duraine, Hugo J. Bellen, David S. Goldstein, Sophia Y. Tsai, Ming-Jer Tsai

1008869
Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)

Ciana Deveau, Xiaodong Jiao, Sachihiro C. Suzuki, Asha Krishnakumar, Takeshi Yoshimatsu, J Fielding Hejtmancik, Ralph F. Nelson

1008873
Suppression of class I compensated cell enlargement by xs2 mutation is mediated by salicylic acid signaling

Fujikura Ushio, Kazune Ezaki, Gorou Horiguchi, Mitsunori Seo, Yuri Kanno, Yuji Kamiya, Michael Lenhard, Hirokazu Tsukaya, Ushio Fujikura

1008877
Protein-protein interaction network controlling establishment and maintenance of switchable cell polarity

Luís António Menezes Carreira, Filipe Tostevin, Ulrich Gerland, Lotte Søgaard-Andersen

1008881
Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes

Selma S. Alkafeef, Shelley Lane, Clinton Yu, Tingting Zhou, Norma V. Solis, Scott G. Filler, Lan Huang, Haoping Liu

1008885
Regulation of epithelial integrity and organ growth by Tctp and Coracle in Drosophila

Sung-Ryeong Lee, Sung-Tae Hong, Kwang-Wook Choi

1008890
The brachyceran de novo gene PIP82, a phosphorylation target of aPKC, is essential for proper formation and maintenance of the rhabdomeric photoreceptor apical domain in Drosophila

Andrew C. Zelhof, Simpla Mahato, Xulong Liang, Jonathan Rylee, Emma Bergh, Lauren E. Feder, Matthew E. Larsen, Steven G. Britt, Markus Friedrich

1008892
Reciprocal regulation between nicotinamide adenine dinucleotide metabolism and abscisic acid and stress response pathways in Arabidopsis

Yechun Hong, Zhen Wang, Huazhong Shi, Juanjuan Yao, Xue Liu, Fuxing Wang, Liang Zeng, Zhi Xie, Jian-Kang Zhu

1008894
AXR1 affects DNA methylation independently of its role in regulating meiotic crossover localization

Nicolas Christophorou, Wenjing She, Jincheng Long, Aurélie Hurel, Sébastien Beaubiat, Yassir Idir, Marina Tagliaro-Jahns, Aurélie Chambon, Victor Solier, Daniel Vezon, Mathilde Grelon, Xiaoqi Feng, Nicolas Bouché, Christine Mézard

1008897
c-di-GMP inhibits LonA-dependent proteolysis of TfoY in Vibrio cholerae

Avatar Joshi, Samar A. Mahmoud, Soo-Kyoung Kim, Justyne L. Ogdahl, Vincent T. Lee, Peter Chien, Fitnat H. Yildiz

1008902
All three mammalian MutL complexes are required for repeat expansion in a mouse cell model of the Fragile X-related disorders

Carson J. Miller, Geum-Yi Kim, Xiaonan Zhao, Karen Usdin

1008905
Active transcription and Orc1 drive chromatin association of the AAA+ ATPase Pch2 during meiotic G2/prophase

Richard Cardoso da Silva, María Ascensión Villar-Fernández, Gerben Vader


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