PLOS Genetics - Číslo 10/2019

Perspective

1008372
Mck1 kinase is a new player in the DNA damage checkpoint pathway

Nerea Sanvisens Delgado, David P. Toczyski


Expression of Concern

1008436
Expression of Concern: Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease

Editorial

1008437
Evaluating the strength of genetic results: Risks and responsibilities

Gregory S. Barsh, Gregory M. Cooper, Gregory P. Copenhaver, Giorgio Sirugo, Hua Tang, Scott M. Williams


Topic Page

1008271
Viral quasispecies

Esteban Domingo, Celia Perales


Research Article

1008067
HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development

Li Li, Isana Veksler-Lublinsky, Anna Zinovyeva

1008096
Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice

Zhaoyang Liu, Garrett W. D. Easson, Jingjing Zhao, Nadja Makki, Nadav Ahituv, Matthew J. Hilton, Simon Y. Tang, Ryan S. Gray

1008223
Local adaptation drives the diversification of effectors in the fungal wheat pathogen Parastagonospora nodorum in the United States

Jonathan K. Richards, Eva H. Stukenbrock, Jessica Carpenter, Zhaohui Liu, Christina Cowger, Justin D. Faris, Timothy L. Friesen

1008232
Biofilm-associated toxin and extracellular protease cooperatively suppress competitors in Bacillus subtilis biofilms

Kazuo Kobayashi, Yukako Ikemoto

1008263
Mutations of the Bacillus subtilis YidC1 (SpoIIIJ) insertase alleviate stress associated with σM-dependent membrane protein overproduction

Heng Zhao, Ankita J. Sachla, John D. Helmann

1008279
A functional regulatory variant of MYH3 influences muscle fiber-type composition and intramuscular fat content in pigs

In-Cheol Cho, Hee-Bok Park, Jin Seop Ahn, Sang-Hyun Han, Jae-Bong Lee, Hyun-Tae Lim, Chae-Kyoung Yoo, Eun-Ji Jung, Dong-Hwan Kim, Wu-Sheng Sun, Yuliaxis Ramayo-Caldas, Sang-Geum Kim, Yong-Jun Kang, Yoo-Kyung Kim, Hyun-Sook Shin, Pil-Nam Seong, In-Sul Hwang, Beom-Young Park, Seongsoo Hwang, Sung-Soo Lee, Youn-Chul Ryu, Jun-Heon Lee, Moon-Suck Ko, Kichoon Lee, Göran Andersson, Miguel Pérez-Enciso, Jeong-Woong Lee

1008341
INX-18 and INX-19 play distinct roles in electrical synapses that modulate aversive behavior in Caenorhabditis elegans

Lisa Voelker, Bishal Upadhyaya, Denise M. Ferkey, Sarah Woldemariam, Noelle D. L’Etoile, Ithai Rabinowitch, Jihong Bai

1008353
MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

Louise A. C. Millard, Marcus R. Munafò, Kate Tilling, Robyn E. Wootton, George Davey Smith

1008354
Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency

Peiheng Gan, Michaela Patterson, Alexa Velasquez, Kristy Wang, Di Tian, Jolene J. Windle, Ge Tao, Daniel P. Judge, Takako Makita, Thomas J. Park, Henry M. Sucov

1008355
Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells

Edwige B. Garcin, Stéphanie Gon, Meghan R. Sullivan, Gregory J. Brunette, Anne De Cian, Jean-Paul Concordet, Carine Giovannangeli, Wilhelm G. Dirks, Sonja Eberth, Kara A. Bernstein, Rohit Prakash, Maria Jasin, Mauro Modesti

1008356
Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons

Fangke Xu, Elzbieta Kula-Eversole, Marta Iwanaszko, Chunghun Lim, Ravi Allada

1008357
Genetic factors define CPO and CLO subtypes of nonsyndromicorofacial cleft

Lulin Huang, Zhonglin Jia, Yi Shi, Qin Du, Jiayu Shi, Ziyan Wang, Yandong Mou, Qingwei Wang, Bihe Zhang, Qing Wang, Shi Ma, He Lin, Shijun Duan, Bin Yin, Yansong Lin, Yiru Wang, Dan Jiang, Fang Hao, Lin Zhang, Haixin Wang, Suyuan Jiang, Huijuan Xu, Chengwei Yang, Chenghao Li, Jingtao Li, Bing Shi, Zhenglin Yang

1008362
The quorum sensing transcription factor AphA directly regulates natural competence in Vibrio cholerae

James R. J. Haycocks, Gemma Z. L. Warren, Lucas M. Walker, Jennifer L. Chlebek, Triana N. Dalia, Ankur B. Dalia, David C. Grainger

1008401
A small set of conserved genes, including sp5 and Hox, are activated by Wnt signaling in the posterior of planarians and acoels

Aneesha G. Tewari, Jared H. Owen, Christian P. Petersen, Daniel E. Wagner, Peter W. Reddien

1008405
Causal relationships between obesity and the leading causes of death in women and men

Jenny C. Censin, Sanne A. E. Peters, Jonas Bovijn, Teresa Ferreira, Sara L. Pulit, Reedik Mägi, Anubha Mahajan, Michael V. Holmes, Cecilia M. Lindgren

1008408
Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice

Luca Madaro, Alessio Torcinaro, Marco De Bardi, Federica F. Contino, Mattia Pelizzola, Giuseppe R. Diaferia, Giulia Imeneo, Marina Bouchè, Pier Lorenzo Puri, Francesca De Santa

1008409
Optimizing clinical exome design and parallel gene-testing for recessive genetic conditions in preconception carrier screening: Translational research genomic data from 14,125 exomes

Antonio Capalbo, Roberto Alonso Valero, Jorge Jimenez-Almazan, Pere Mir Pardo, Marco Fabiani, David Jiménez, Carlos Simon, Julio Rodriguez Martin

1008410
Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms

Diana Bahhir, Cagri Yalgin, Liina Ots, Sampsa Järvinen, Jack George, Alba Naudí, Tatjana Krama, Indrikis Krams, Mairi Tamm, Ana Andjelković, Eric Dufour, Jose M. González de Cózar, Mike Gerards, Mikael Parhiala, Reinald Pamplona, Howard T. Jacobs, Priit Jõers

1008411
TSEN54 missense variant in Standard Schnauzers with leukodystrophy

Theresa Störk, Jasmin Nessler, Linda Anderegg, Enrice Hünerfauth, Isabelle Schmutz, Vidhya Jagannathan, Kaisa Kyöstilä, Hannes Lohi, Wolfgang Baumgärtner, Andrea Tipold, Tosso Leeb

1008412
Centromeric SMC1 promotes centromer clustering and stabilizes meiotic homolog pairing

Talia Hatkevich, Vincent Boudreau, Thomas Rubin, Paul S. Maddox, Jean-René Huynh, Jeff Sekelsky

1008416
A RAPGEF6 variant constitutes a major risk factor for laryngeal paralysis in dogs

Sheida Hadji Rasouliha, Laura Barrientos, Linda Anderegg, Carina Klesty, Jessica Lorenz, Lucie Chevallier, Vidhya Jagannathan, Sarah Rösch, Tosso Leeb

1008419
GPCR-mediated glucose sensing system regulates light-dependent fungal development and mycotoxin production

Thaila Fernanda dos Reis, Laura Mellado, Jessica M. Lohmar, Lilian Pereira Silva, Jing-Jiang Zhou, Ana M. Calvo, Gustavo H. Goldman, Neil A. Brown

1008423
Kinetochore-associated Stu2 promotes chromosome biorientation in vivo

Matthew P. Miller, Rena K. Evans, Alex Zelter, Elisabeth A. Geyer, Michael J. MacCoss, Luke M. Rice, Trisha N. Davis, Charles L. Asbury, Sue Biggins

1008424
Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice

Jaroslawna Meister, Derek B. J. Bone, Grzegorz Godlewski, Ziyi Liu, Regina J. Lee, Sergey A. Vishnivetskiy, Vsevolod V. Gurevich, Danielle Springer, George Kunos, Jürgen Wess

1008425
NusG prevents transcriptional invasion of H-NS-silenced genes

Lionello Bossi, Mathilde Ratel, Camille Laurent, Patricia Kerboriou, Andrew Camilli, Eric Eveno, Marc Boudvillain, Nara Figueroa-Bossi

1008430
The effects of manipulating levels of replication initiation factors on origin firing efficiency in yeast

Kelsey L. Lynch, Gina M. Alvino, Elizabeth X. Kwan, Bonita J. Brewer, M. K. Raghuraman

1008431
Bayesian multivariate reanalysis of large genetic studies identifies many new associations

Michael C. Turchin, Matthew Stephens

1008434
Bacillus subtilis PgcA moonlights as a phosphoglucosamine mutase in support of peptidoglycan synthesis

Vaidehi Patel, Katherine A. Black, Kyu Y. Rhee, John D. Helmann

1008435
Protease-associated import systems are widespread in Gram-negative bacteria

Rhys Grinter, Pok Man Leung, Lakshmi C. Wijeyewickrema, Dene Littler, Simone Beckham, Robert N. Pike, Daniel Walker, Chris Greening, Trevor Lithgow

1008438
Spatiotemporal cytoskeleton organizations determine morphogenesis of multicellular trichomes in tomato

Jiang Chang, Zhijing Xu, Meng Li, Meina Yang, Haiyang Qin, Jie Yang, Shuang Wu

1008439
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression

Parmanand Malvi, Radoslav Janostiak, Arvindhan Nagarajan, Guoping Cai, Narendra Wajapeyee

1008441
Histone deposition promotes recombination-dependent replication at arrested forks

Julien Hardy, Dingli Dai, Anissia Ait Saada, Ana Teixeira-Silva, Louise Dupoiron, Fatemeh Mojallali, Karine Fréon, Francoise Ochsenbein, Brigitte Hartmann, Sarah Lambert

1008443
Synergistic action of the transcription factors Krüppel homolog 1 and Hairy in juvenile hormone/Methoprene-tolerant-mediated gene-repression in the mosquito Aedes aegypti

Tusar T. Saha, Sourav Roy, Gaofeng Pei, Wei Dou, Zhen Zou, Alexander S. Raikhel

1008444
Low affinity binding sites in an activating CRM mediate negative autoregulation of the Drosophila Hox gene Ultrabithorax

Rebecca K. Delker, Vikram Ranade, Ryan Loker, Roumen Voutev, Richard S. Mann

1008445
A novel system of bacterial cell division arrest implicated in horizontal transmission of an integrative and conjugative element

Sotaro Takano, Kohei Fukuda, Akiko Koto, Ryo Miyazaki

1008448
PilT and PilU are homohexameric ATPases that coordinate to retract type IVa pili

Jennifer L. Chlebek, Hannah Q. Hughes, Aleksandra S. Ratkiewicz, Rasman Rayyan, Joseph Che-Yen Wang, Brittany E. Herrin, Triana N. Dalia, Nicolas Biais, Ankur B. Dalia

1008451
The comprehensive role of E-cadherin in maintaining prostatic epithelial integrity during oncogenic transformation and tumor progression

Adam Olson, Vien Le, Joseph Aldahl, Eun-Jeong Yu, Erika Hooker, Yongfeng He, Dong-Hong Lee, Won Kyung Kim, Robert D. Cardiff, Joseph Geradts, Zijie Sun

1008453
Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle

Xue Li, Sudhir Kumar, Marina McDew-White, Meseret Haile, Ian H. Cheeseman, Scott Emrich, Katie Button-Simons, Francois Nosten, Stefan H. I. Kappe, Michael T. Ferdig, Tim J. C. Anderson, Ashley M. Vaughan

1008460
A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing

Tao Chen, Bin Zhang, Thomas Ziegenhals, Archana B. Prusty, Sebastian Fröhler, Clemens Grimm, Yuhui Hu, Bernhard Schaefke, Liang Fang, Min Zhang, Nadine Kraemer, Angela M. Kaindl, Utz Fischer, Wei Chen

1008464
CRISPR editing of sftb-1/SF3B1 in Caenorhabditis elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing

Xènia Serrat, Dmytro Kukhtar, Eric Cornes, Anna Esteve-Codina, Helena Benlloch, Germano Cecere, Julián Cerón

1008465
Nitrate-responsive OBP4-XTH9 regulatory module controls lateral root development in Arabidopsis thaliana

Peipei Xu, Weiming Cai

1008466
Paralog buffering contributes to the variable essentiality of genes in cancer cell lines

Barbara De Kegel, Colm J. Ryan

1008474
Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance

Zhenxing Liu, Christine A. Tabuloc, Yongbo Xue, Yao Cai, Pearson Mcintire, Ye Niu, Vu H. Lam, Joanna C. Chiu, Yong Zhang

1008479
Duplicate divergence of two bacterial small heat shock proteins reduces the demand for Hsp70 in refolding of substrates

Igor Obuchowski, Artur Piróg, Milena Stolarska, Bartłomiej Tomiczek, Krzysztof Liberek


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