Vaccinomics – The future of personalized vaccination?

Česká verze

Authors: A. Markocsy ^1,2 ; I. Urbančíková ^3,4,5 ; A. Čereš ² ; A. Ružinák Bobčáková ^1,2,6 ; O. Petrovičová ^1,2,6 ; M. Jeseňák ^1,2,6
Authors place of work: Klinika detí a dorastu, Jesseniova lekárska fakulta v Martine, Univerzita Komenského v Bratislave a Univerzitná nemocnica Martin, Slovensko ¹; Ústav klinickej imunológie a lekárskej genetiky, Jesseniova lekárska fakulta v Martine, Univerzita Komenského v Bratislave a Univerzitná nemocnica Martin, Slovensko ²; Klinika detí a dorastu, Lekárska fakulta, Univerzita Pavla Jozefa Šafárika v Košiciach a Detská fakultná nemocnica v Košiciach, Slovensko ³; Ústav epidemiológie, Lekárska fakulta, Univerzita Pavla Jozefa Šafárika v Košiciach, Slovensko ⁴; Klinika infektológie a cestovnej medicíny, Lekárska fakulta, Univerzita Pavla Jozefa Šafárika v Košiciach a Univerzitná nemocnica L. Pasteura Košice, Slovensko ⁵; Klinika pneumológie a ftizeológie, Jesseniova lekárska fakulta v Martine, Univerzita Komenského v Bratislave a Univerzitná nemocnica Martin, Slovensko ⁶
Published in the journal: Epidemiol. Mikrobiol. Imunol. 75, 2026, č. 3, s. 113-121
Category: Souhrnné sdělení
doi: https://doi.org/10.61568/emi/11-6760/20260624/143936

Summary

Vaccination is one of the most effective methods for the prevention of infectious diseases. Selected types of vaccines are administered to the majority of the population, thereby supporting herd immunity against certain transmissible diseases. Importantly, the immune response to vaccines –⁠ regarding its intensity, complexity, and duration –⁠ varies among individuals. These differences are partly influenced by genetic factors, specifically the presence of selected genetic polymorphisms that may affect not only the effectiveness of the immune response but also the risk of adverse reactions. Vaccinomics is a research field focused on the study of genomic and molecular biological characteristics of the human organism with the aim of elucidating the causes of interindividual differences in immune responses following vaccination. Adversomics deals with adverse reactions after vaccination. Vaccinomics may help to identify individuals who could benefit from alternative vaccination schedules or the selection of specific vaccine types. However, the majority of associations reported to date still require independent validation.

Keywords:

vaccination – Genetic polymorphism – vaccinomics – adversomics – DNA variant

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