Odpoveď pH komorového moku králikov na antiglaukomatiká za in vivo podmienok

The pH of the Rabbit’s Aqueous Humor Response on Antiglaucomatics

In this contribution the activity of antiglaucomatics - 2% pilocarpine (pH 5,98),0,5% timoptol (pH 6,58) and 0,005% xalatan (pH 6,83) is emphasized from the viewof pH values and changes of the pH values of the rabbit aqueous humor in vitroafter their application. The rabbit’s aqueous humor pH is 7,59 - similar to thehuman healthy eye (7,5 - 7,6). We observed that these antiglaucomatics decreasethe aqueous humor pH to the acid levels in the following order: 2% pilocarpine> 0,5% timoptol > 0,005% xalatan. The most significant decrease was measuredimmediately after the application. From the view of speed of response andeffectivity in time achieving the pH of the normal aqueous humor we constate thefollowing order: 0,005% xalatan > 0,5% timoptol > 2% pilocarpine. The changes inpH of the aqueous humor after application of these antiglaucomatics are directlyconnect with their physiologic function in the eye. Moreover, they also point outthe importance of the pH dependence of the antiglaucomatics applicated into theconjunctival sac in the treat-ment of the glaucoma disease.

Key words:
changes in pH of the aqueous humor of the rabbits after applicationof antiglaucomatics