Gastroprotection in long-term use of non-steroidal antirheumatic drugs and low-dose acetylosalicylic acid

Česká verze

Authors: M. Bátovský
Authors place of work: Gastroenterologická klinika FNsP a SZU
Published in the journal: Gastroent Hepatol 2010; 64(3): 18-23
Category: IBD: Aktuální přehled

Summary

The incidence of non-steroidal anti-inflammatory drug /NSA/-related and low-dose acetylosalicylic acid /LD-ASA/-related ulcer complications remains high despite the availability of potent anti-ulcer drugs and selective cyclo-oxygenase-2 inhibitors. These complications can be minimized by a prospective assessment of the patient’s baseline risk, rational choice and use of NSA drugs and selective use of a co-therapy strategy with gastroprotectives. The presence of H. pylori infection significantly increases the risk of upper gastrointestinal complications in NSA drug users, suggesting that all patients requiring regular long-term NSA/LS-ASA drug therapy should be tested for H. pylori.

Key words:
gastroprotection –⁠ non-steroidal anti-inflammatory drugs –⁠ acetylosalicylic acid –⁠ Helicobacter pylori –⁠ proton pump inhibitors

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