The monoclonal antibody daratumumab in the treatment of multiple myeloma

Česká verze

Authors: M. Štork; L. Pour; V. Sandecká; M. Krejčí; Z. Adam; Z. Král
Authors place of work: Interní hematologická a onkologická klinika, FN Brno
Published in the journal: Transfuze Hematol. dnes,22, 2016, No. 4, p. 230-237.
Category: Souhrnné práce, původní práce, kazuistiky

Summary

The monoclonal antibody daratumumab is a new and effective drug for the treatment of multiple myeloma. Results of clinical trials have demonstrated a high efficacy in monotherapy and an even higher when used in combination. Daratumumab monotherapy in heavily-pre-treated patients showed a 30% overall response rate with response persisting for more than six months. Combination of daratumumab and immunomodulatory drugs has shown a more than 90% response rate and significant extension of progression-free survival versus standard care in relapsed patients. This review summarizes current preclinical and clinical data on daratumumab treatment in multiple myeloma.

Key words:
multiple myeloma –⁠ daratumumab –⁠ CD38 –⁠ monoclonal antibody

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