National and regional prevalence of posttraumatic stress disorder in sub-Saharan Africa: A systematic review and meta-analysis


Autoři: Lauren C. Ng aff001;  Anne Stevenson aff002;  Sreeja S. Kalapurakkel aff003;  Charlotte Hanlon aff005;  Soraya Seedat aff006;  Boniface Harerimana aff007;  Bonginkosi Chiliza aff008;  Karestan C. Koenen aff009
Působiště autorů: Department of Psychology, University of California Los Angeles, Los Angeles, California, United States of America aff001;  Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America aff002;  Duke University Global Health Institute, Durham, North Carolina, United States of America aff003;  Centre for Global Mental Health, Health Service and Population Research, Department Institute of Psychiatry, Psychology and Neuroscience King’s College, London, United Kingdom aff004;  Department of Psychiatry, Stellenbosch University, Cape Town, South Africa aff005;  Faculty of Health Sciences, Western University, London, Ontario, Canada aff006;  College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda aff007;  Department of Psychiatry, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa aff008;  Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America aff009
Vyšlo v časopise: National and regional prevalence of posttraumatic stress disorder in sub-Saharan Africa: A systematic review and meta-analysis. PLoS Med 17(5): e32767. doi:10.1371/journal.pmed.1003090
Kategorie: Research Article
doi: 10.1371/journal.pmed.1003090

Souhrn

Background

People living in sub-Saharan Africa (SSA) are disproportionately exposed to trauma and may be at increased risk for posttraumatic stress disorder (PTSD). However, a dearth of population-level representative data from SSA is a barrier to assessing PTSD. This manuscript sought to calculate pooled PTSD prevalence estimates from nationally and regionally representative surveys in SSA.

Methods and findings

The search was conducted in PubMed, Embase, PsycINFO, and PTSDpubs and was last run between October 18, 2019, and November 11, 2019. We included studies that were published in peer-reviewed journals; used probabilistic sampling methods and systematic PTSD assessments; and included ≥ 450 participants who were current residents of an SSA country, at least 50% of whom were aged between 15 and 65 years. The primary outcomes were point prevalence estimates of PTSD across all studies, and then within subgroups. The protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) (registration number CRD42016029441). Out of 2,825 unique articles reviewed, 25 studies including a total of 58,887 eligible participants (54% female) in 10 out of the 48 countries in SSA were identified. Most studies enrolled any adult aged 18 years or older. However, some studies only enrolled specific age brackets or persons as young as 15 years old. Six studies were national surveys, and 19 were regional.

There were 4 key findings in the meta-analysis: (1) the overall pooled prevalence of probable PTSD was 22% (95% CI 13%–32%), while the current prevalence—defined as 1 week to 1 month—was 25% (95% CI 16%–36%); (2) prevalence estimates were highly variable, ranging from 0% (95% CI 0%–0%) to 74% (95% CI 72%–76%); (3) conflict-unexposed regions had a pooled prevalence of probable PTSD of 8% (95% CI 3%–15%), while conflict-exposed regions had a pooled prevalence of probable PTSD of 30% (95% CI 21%–40%; p < 0.001); and (4) there was no significant difference in the pooled prevalence of PTSD for men and women. The primary limitations of our methodology are our exclusion of the following study types: those published in languages other than English, French, and Portuguese; smaller studies; those that focused on key populations; those that reported only on continuous measures of PTSD symptoms; and unpublished or non–peer-reviewed studies.

Conclusions

In this study, PTSD symptoms consistent with a probable diagnosis were found to be common in SSA, especially in regions exposed to armed conflict. However, these studies only represent data from 10 of the 48 SSA countries, and only 6 studies provided national-level data. Given the enormous heterogeneity expected across the continent, and also within countries and regions, this review cannot speak to rates of PTSD in any regions not included in this review. Thus, substantial gaps in our knowledge of PTSD prevalence in SSA remain. More research on population-level prevalence is needed to determine the burden of trauma symptoms and PTSD in SSA and to identify acceptable and feasible approaches to address this burden given limited mental healthcare resources.

Klíčová slova:

Adults – Africa – Mental health and psychiatry – Metaanalysis – Post-traumatic stress disorder – Research validity – Systematic reviews – War and civil unrest


Zdroje

1. Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet. 2013;382(9904):1575–86. Epub 2013/09/03. doi: 10.1016/S0140-6736(13)61611-6 23993280.

2. Koenen KC, Ratanatharathorn A, Ng L, McLaughlin KA, Bromet EJ, Stein DJ, et al. Posttraumatic stress disorder in the World Mental Health Surveys. Psychological medicine. 2017;47(13):2260–74. Epub 2017/04/08. doi: 10.1017/S0033291717000708 28385165; PubMed Central PMCID: PMC6034513.

3. Kessler RC. Posttraumatic stress disorder: the burden to the individual and to society. J Clin Psychiatry. 2000;61 Suppl 5:4–12; discussion 3–4. Epub 2000/04/13. 10761674.

4. Karam EG, Friedman MJ, Hill ED, Kessler RC, McLaughlin KA, Petukhova M, et al. Cumulative traumas and risk thresholds: 12-month PTSD in the World Mental Health (WMH) surveys. Depression and anxiety. 2014;31(2):130–42. Epub 2013/08/29. doi: 10.1002/da.22169 23983056; PubMed Central PMCID: PMC4085043.

5. Kessler RC, Aguilar-Gaxiola S, Alonso J, Benjet C, Bromet EJ, Cardoso G, et al. Trauma and PTSD in the WHO World Mental Health Surveys. Eur J Psychotraumatol. 2017;8(sup5):1353383. Epub 2017/10/28. doi: 10.1080/20008198.2017.1353383 29075426; PubMed Central PMCID: PMC5632781.

6. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;15.

7. Baxter AJ, Patton G, Scott KM, Degenhardt L, Whiteford HA. Global epidemiology of mental disorders: what are we missing? PloS one. 2013;8(6):e65514. Epub 2013/07/05. doi: 10.1371/journal.pone.0065514 23826081; PubMed Central PMCID: PMC3691161.

8. World Health Organization. WHO | mhGAP Mental Health Gap Action Programme [Internet]. World Health Organization. 2008 [cited 2015 Dec 15]. Available from: http://www.who.int/mental_health/evidence/mhGAP/en/index.html.

9. World Health Organization. Global and regional estimates of violence against women: prevalence and health effects of intimate partner violence and non- partner sexual violence. Geneva: 2013.

10. Abrahams N, Devries K, Watts C, Pallitto C, Petzold M, Shamu S, et al. Worldwide prevalence of non-partner sexual violence: a systematic review. Lancet. 2014;383(9929):1648–54. Epub 2014/02/18. doi: 10.1016/S0140-6736(13)62243-6 24529867.

11. Bundis Entwicklung Hilft. World Risk Report Analysis and prospects 2017. 2017.

12. Marc A. CONFLICT AND VIOLENCE IN THE 21ST CENTURY CURRENT TRENDS AS OBSERVED IN EMPIRICAL RESEARCH AND STATISTICS. World Bank Group.

13. The World Bank. Fragile and conflict affected situations: World Bank Group; 2019 [cited 2019 July 11]. Available from: https://data.worldbank.org/region/fragile-and-conflict-affected-situations.

14. Fanon F. Black Skin, White Masks. New York: Grove Press; 1952.

15. Saxena S, Thornicroft G, Knapp M, Whiteford H. Resources for mental health: scarcity, inequity, and inefficiency. Lancet. 2007;370(9590):878–89. Epub 2007/09/07. doi: 10.1016/S0140-6736(07)61239-2 17804062.

16. World Health Organization. Mental health atlas. Geneva: WHO Press; 2014.

17. The World Bank. Sub-Saharan Africa: World Bank Group; 2017 [cited 2018 Jan 22]. Available from: https://data.worldbank.org/region/sub-saharan-africa.

18. The World Bank. World Bank Country and Lending Groups: The World Bank Group; 2019 [cited 2019 July 11]. Available from: https://datahelpdesk.worldbank.org/knowledgebase/articles/906519-world-bank-country-and-lending-groups.

19. Kebede D, Alem A, Deyassa N, Shibre T, Negash A, Beyero T. Socio-demographic correlates of depressive disorder in Butajira, rural Ethiopia. Cent Afr J Med. 2003;49(7–8):78–83. Epub 2004/06/25. 15214278.

20. Wang PS, Aguilar-Gaxiola S, Alonso J, Angermeyer MC, Borges G, Bromet EJ, et al. Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys. Lancet. 2007;370(9590):841–50. Epub 2007/09/11. doi: 10.1016/S0140-6736(07)61414-7 17826169; PubMed Central PMCID: PMC2847360.

21. Eaton J, McCay L, Semrau M, Chatterjee S, Baingana F, Araya R, et al. Scale up of services for mental health in low-income and middle-income countries. Lancet. 2011;378(9802):1592–603. Epub 2011/10/20. doi: 10.1016/S0140-6736(11)60891-X 22008429.

22. Charlson FJ, Flaxman A, Ferrari AJ, Vos T, Steel Z, Whiteford HA. Post-traumatic stress disorder and major depression in conflict-affected populations: an epidemiological model and predictor analysis. Global Mental Health. 2016;3:e4. doi: 10.1017/gmh.2015.26 28596873

23. Bromet EJ, Atwoli L, Kawakami N, Navarro-Mateu F, Piotrowski P, King AJ, et al. Post-traumatic stress disorder associated with natural and human-made disasters in the World Mental Health Surveys. Psychological medicine. 2017;47(2):227–41. Epub 2016/08/31. doi: 10.1017/S0033291716002026 27573281; PubMed Central PMCID: PMC5432967.

24. Rasmussen A, Nguyen L, Wilkinson J, Vundla S, Raghavan S, Miller KE, et al. Rates and impact of trauma and current stressors among Darfuri refugees in Eastern Chad. The American journal of orthopsychiatry. 2010;80(2):227–36. Epub 2010/06/18. doi: 10.1111/j.1939-0025.2010.01026.x 20553516; PubMed Central PMCID: PMC2920620.

25. Mels C, Derluyn I, Broekaert E, Rosseel Y. The psychological impact of forced displacement and related risk factors on Eastern Congolese adolescents affected by war. Journal of child psychology and psychiatry, and allied disciplines. 2010;51(10):1096–104. Epub 2010/03/30. doi: 10.1111/j.1469-7610.2010.02241.x 20345839.

26. de Jong JT, Komproe IH, Van Ommeren M, El Masri M, Araya M, Khaled N, et al. Lifetime events and posttraumatic stress disorder in 4 postconflict settings. JAMA: the journal of the American Medical Association. 2001;286(5):555–62. Epub 2001/08/14. doi: 10.1001/jama.286.5.555 11476657.

27. Salah TT, Abdelrahman A, Lien L, Eide AH, Martinez P, Hauff E. The mental health of internally displaced persons: an epidemiological study of adults in two settlements in Central Sudan. The International journal of social psychiatry. 2013;59(8):782–8. Epub 2012/09/18. doi: 10.1177/0020764012456810 22982816.

28. Karunakara UK, Neuner F, Schauer M, Singh K, Hill K, Elbert T, et al. Traumatic events and symptoms of post-traumatic stress disorder amongst Sudanese nationals, refugees and Ugandans in the West Nile. Afr Health Sci. 2004;4(2):83–93. Epub 2004/10/13. 15477186; PubMed Central PMCID: PMC2141616.

29. Onyut LP, Neuner F, Ertl V, Schauer E, Odenwald M, Elbert T. Trauma, poverty and mental health among Somali and Rwandese refugees living in an African refugee settlement—an epidemiological study. Conflict and health. 2009;3:6. Epub 2009/05/28. doi: 10.1186/1752-1505-3-6 19470171; PubMed Central PMCID: PMC2695430.

30. Roberts B, Ocaka KF, Browne J, Oyok T, Sondorp E. Factors associated with post-traumatic stress disorder and depression amongst internally displaced persons in northern Uganda. BMC psychiatry. 2008;8:38. Epub 2008/05/21. doi: 10.1186/1471-244X-8-38 18489768; PubMed Central PMCID: PMC2397420.

31. Ndetei DM, Khasakhala L, Maru H, Pizzo M, Mutiso V, Ongecha-Owuor FA, et al. Clinical epidemiology in patients admitted at Mathari Psychiatric Hospital, Nairobi, Kenya. Social psychiatry and psychiatric epidemiology. 2008;43(9):736–42. Epub 2008/05/10. doi: 10.1007/s00127-008-0360-y 18465102.

32. Mahenge B, Likindikoki S, Stockl H, Mbwambo J. Intimate partner violence during pregnancy and associated mental health symptoms among pregnant women in Tanzania: a cross-sectional study. Bjog. 2013;120(8):940–6. Epub 2013/03/08. doi: 10.1111/1471-0528.12185 23464524.

33. Whetten K, Shirey K, Pence BW, Yao J, Thielman N, Whetten R, et al. Trauma history and depression predict incomplete adherence to antiretroviral therapies in a low income country. PloS one. 2013;8(10):e74771. Epub 2013/10/15. doi: 10.1371/journal.pone.0074771 24124455; PubMed Central PMCID: PMC3790775.

34. Kinyanda E, Hoskins S, Nakku J, Nawaz S, Patel V. The prevalence and characteristics of suicidality in HIV/AIDS as seen in an African population in Entebbe district, Uganda. BMC psychiatry. 2012;12:63. Epub 2012/06/21. doi: 10.1186/1471-244X-12-63 22713589; PubMed Central PMCID: PMC3395571.

35. Peltzer K, Naidoo P, Matseke G, Louw J, McHunu G, Tutshana B. Prevalence of post-traumatic stress symptoms and associated factors in tuberculosis (TB), TB retreatment and/or TB-HIV co-infected primary public health-care patients in three districts in South Africa. Psychology, health & medicine. 2013;18(4):387–97. Epub 2012/10/16. doi: 10.1080/13548506.2012.726364 23061988.

36. El-Sayed AM, Hadley C, Tessema F, Tegegn A, Cowan JA Jr., Galea S. Back and neck pain and psychopathology in rural sub-Saharan Africa: evidence from the Gilgel Gibe Growth and Development Study, Ethiopia. Spine (Phila Pa 1976). 2010;35(6):684–9. Epub 2010/02/09. doi: 10.1097/BRS.0b013e3181b4926e 20139812; PubMed Central PMCID: PMC2891327.

37. Adewuya AO, Ologun YA, Ibigbami OS. Post-traumatic stress disorder after childbirth in Nigerian women: prevalence and risk factors. BJOG. 2006;113(3):284–8. Epub 2006/02/21. doi: 10.1111/j.1471-0528.2006.00861.x 16487199.

38. Chhagan MK, Mellins CA, Kauchali S, Craib MH, Taylor M, Kvalsvig JD, et al. Mental health disorders among caregivers of preschool children in the Asenze study in KwaZulu-Natal, South Africa. Maternal and child health journal. 2014;18(1):191–9. Epub 2013/03/08. doi: 10.1007/s10995-013-1254-5 23467845; PubMed Central PMCID: PMC3708993.

39. Kuo C, Operario D. Health of adults caring for orphaned children in an HIV-endemic community in South Africa. AIDS care. 2011;23(9):1128–35. Epub 2011/04/12. doi: 10.1080/09540121.2011.554527 21480009; PubMed Central PMCID: PMC3139727.

40. Ertl V, Saile R, Neuner F, Catani C. Drinking to ease the burden: a cross-sectional study on trauma, alcohol abuse and psychopathology in a post-conflict context. BMC psychiatry. 2016;16:202. Epub 2016/06/28. doi: 10.1186/s12888-016-0905-7 27342048; PubMed Central PMCID: PMC4921056.

41. Verelst A, De Schryver M, Broekaert E, Derluyn I. Mental health of victims of sexual violence in eastern Congo: associations with daily stressors, stigma, and labeling. BMC women's health. 2014;14:106. Epub 2014/09/10. doi: 10.1186/1472-6874-14-106 25195041; PubMed Central PMCID: PMC4237834.

42. Mels C, Derluyn I, Broekaert E, Rosseel Y. Screening for traumatic exposure and posttraumatic stress symptoms in adolescents in the war-affected eastern Democratic Republic of Congo. Archives of pediatrics & adolescent medicine. 2009;163(6):525–30. Epub 2009/06/03. doi: 10.1001/archpediatrics.2009.56 19487608.

43. Othieno CJ, Okoth R, Peltzer K, Pengpid S, Malla LO. Traumatic experiences, posttraumatic stress symptoms, depression, and health-risk behavior in relation to injury among University of Nairobi students in Kenya. Int J Psychiatry Med. 2015;50(3):299–316. Epub 2015/11/13. doi: 10.1177/0091217415610310 26561275.

44. Oladeji BD, Morakinyo JJ, Gureje O. Traumatic events and post-traumatic stress symptoms among adolescents in Ibadan. African journal of medicine and medical sciences. 2011;40(1):23–31. Epub 2011/08/13. 21834258.

45. Neugebauer R, Fisher PW, Turner JB, Yamabe S, Sarsfield JA, Stehling-Ariza T. Post-traumatic stress reactions among Rwandan children and adolescents in the early aftermath of genocide. International journal of epidemiology. 2009;38(4):1033–45. doi: 10.1093/ije/dyn375 19204009.

46. Saile R, Ertl V, Neuner F, Catani C. Does war contribute to family violence against children? Findings from a two-generational multi-informant study in Northern Uganda. Child abuse & neglect. 2014;38(1):135–46. Epub 2013/11/19. doi: 10.1016/j.chiabu.2013.10.007 24239222.

47. Okello J, Nakimuli-Mpungu E, Musisi S, Broekaert E, Derluyn I. War-related trauma exposure and multiple risk behaviors among school-going adolescents in Northern Uganda: the mediating role of depression symptoms. Journal of affective disorders. 2013;151(2):715–21. Epub 2013/09/10. doi: 10.1016/j.jad.2013.07.030 24012069.

48. O'Donnell DA, Roberts WC, Schwab-Stone ME. Community violence exposure and post-traumatic stress reactions among Gambian youth: the moderating role of positive school climate. Social psychiatry and psychiatric epidemiology. 2011;46(1):59–67. doi: 10.1007/s00127-009-0162-x 19921080.

49. Seedat S, Nyamai C, Njenga F, Vythilingum B, Stein DJ. Trauma exposure and post-traumatic stress symptoms in urban African schools. Survey in CapeTown and Nairobi. The British journal of psychiatry: the journal of mental science. 2004;184:169–75. Epub 2004/02/03. doi: 10.1192/bjp.184.2.169 14754831.

50. Charlson F, van Ommeren M, Flaxman A, Cornett J, Whiteford H, Saxena S. New WHO prevalence estimates of mental disorders in conflict settings: a systematic review and meta-analysis. Lancet. 2019;394(10194):240–8. Epub 2019/06/16. doi: 10.1016/S0140-6736(19)30934-1 31200992.

51. Hoppen TH, Morina N. The prevalence of PTSD and major depression in the global population of adult war survivors: a meta-analytically informed estimate in absolute numbers. Eur J Psychotraumatol. 2019;10(1):1578637. Epub 2019/03/06. doi: 10.1080/20008198.2019.1578637 30834069; PubMed Central PMCID: PMC6394282.

52. OECD (2020). Working age population (indicator). [cited 27 Apr 2020]. doi: 10.1787/d339918b-en

53. Naing L, Winn T, Rusli B. Practical issues in calculating the sample size for prevalence studies. Archives of orofacial Sciences. 2006;1:9–14.

54. Kohrt BA, Rasmussen A, Kaiser BN, Haroz EE, Maharjan SM, Mutamba BB, et al. Cultural concepts of distress and psychiatric disorders: literature review and research recommendations for global mental health epidemiology. International journal of epidemiology. 2014;43(2):365–406. Epub 2013/12/25. doi: 10.1093/ije/dyt227 24366490; PubMed Central PMCID: PMC3997373.

55. Moher D, Liberati A, Tetzlaff A, Altman DG, PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med. 2009;6(7):e1000097. doi: 10.1371/journal.pmed.1000097 19621072

56. Loney PL, Chambers LW, Bennett KJ, Roberts JG, Stratford PW. Critical appraisal of the health research literature: prevalence or incidence of a health problem. Chronic diseases in Canada. 1998;19(4):170–6. Epub 1999/02/24. 10029513.

57. Shamliyan T, Kane RL, Dickinson S. A systematic review of tools used to assess the quality of observational studies that examine incidence or prevalence and risk factors for diseases. Journal of clinical epidemiology. 2010;63(10):1061–70. Epub 2010/08/24. doi: 10.1016/j.jclinepi.2010.04.014 20728045.

58. International Committee of the Red Cross (ICRC). How is the Term "Armed Conflict" Defined in International Humanitarian Law? March 2008. [cited 27 Apr 2020]. Available from: https://www.icrc.org/en/doc/assets/files/other/opinion-paper-armed-conflict.pdf.

59. StataCorp. Stata Statistical Software: Release 14. College Station, TX: StataCorp LP.; 2015.

60. Nyaga VN, Arbyn M, Aerts M. Metaprop: a Stata command to perform meta-analysis of binomial data. Archives of public health = Archives belges de sante publique. 2014;72(1):39. Epub 2014/01/01. doi: 10.1186/2049-3258-72-39 25810908; PubMed Central PMCID: PMC4373114.

61. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ: British Medical Journal. 2003;327(7414):557–60. doi: 10.1136/bmj.327.7414.557 12958120.

62. Harbord RM, Higgins JPT. Meta-regression in Stata. Stata Journal. 2008;8(4):493–519.

63. Pence BW, Shirey K, Whetten K, Agala B, Itemba D, Adams J, et al. Prevalence of psychological trauma and association with current health and functioning in a sample of HIV-infected and HIV-uninfected Tanzanian adults. PloS one. 2012;7(5):e36304. Epub 2012/05/19. doi: 10.1371/journal.pone.0036304 22606252; PubMed Central PMCID: PMC3351441.

64. Kohli A, Perrin N, Mpanano RM, Case J, Murhula CM, Binkurhorhwa AK, et al. Social interaction in the aftermath of conflict-related trauma experiences among women in Walungu Territory, Democratic Republic of Congo. Global public health. 2015;10(1):55–70. Epub 2014/11/05. doi: 10.1080/17441692.2014.972426 25363537; PubMed Central PMCID: PMC4262667.

65. Ayazi T, Lien L, Eide AH, Jenkins R, Albino RA, Hauff E. Disability associated with exposure to traumatic events: results from a cross-sectional community survey in South Sudan. BMC public health. 2013;13:469. Epub 2013/05/16. doi: 10.1186/1471-2458-13-469 23672785; PubMed Central PMCID: PMC3658891.

66. Jenkins R, Njenga F, Okonji M, Kigamwa P, Baraza M, Ayuyo J, et al. Psychotic symptoms in Kenya—prevalence, risk factors, and relationship with common mental disorders. Int J Environ Res Public Health. 2012;9(5):1748–56. Epub 2012/07/04. doi: 10.3390/ijerph9051748 22754470; PubMed Central PMCID: PMC3386585.

67. Johnson K, Asher J, Rosborough S, Raja A, Panjabi R, Beadling C, et al. Association of combatant status and sexual violence with health and mental health outcomes in postconflict Liberia. JAMA: the journal of the American Medical Association. 2008;300(6):676–90. doi: 10.1001/jama.300.6.676 18698066.

68. Vinck P, Pham PN. Association of exposure to intimate-partner physical violence and potentially traumatic war-related events with mental health in Liberia. Social science & medicine. 2013;77:41–9. Epub 2012/12/12. doi: 10.1016/j.socscimed.2012.10.026 23219850.

69. Eytan A, Munyandamutsa N, Nkubamugisha PM, Gex-Fabry M. Long-term mental health outcome in post-conflict settings: Similarities and differences between Kosovo and Rwanda. The International journal of social psychiatry. 2015;61(4):363–72. Epub 2014/08/26. doi: 10.1177/0020764014547062 25145869.

70. Munyandamutsa N, Nkubamugisha PM, Gex-Fabry M, Eytan A. Mental and physical health in Rwanda 14 years after the genocide. Social psychiatry and psychiatric epidemiology. 2012;47(11):1753–61. doi: 10.1007/s00127-012-0494-9 22402589

71. Jalloh MF, Li W, Bunnell RE, Ethier KA, O’Leary A, Hageman KM, et al. Impact of Ebola experiences and risk perceptions on mental health in Sierra Leone, July 2015. BMJ global health. 2018;3(2):e000471. Epub 2018/04/03. doi: 10.1136/bmjgh-2017-000471 29607096; PubMed Central PMCID: PMC5873549.

72. Atwoli L, Stein DJ, Williams DR, McLaughlin KA, Petukhova M, Kessler RC, et al. Trauma and posttraumatic stress disorder in South Africa: analysis from the South African Stress and Health Study. BMC psychiatry. 2013;13:182. Epub 2013/07/04. doi: 10.1186/1471-244X-13-182 23819543; PubMed Central PMCID: PMC3716970.

73. Atwoli L, Stein DJ, King A, Petukhova M, Aguilar-Gaxiola S, Alonso J, et al. Posttraumatic stress disorder associated with unexpected death of a loved one: Cross-national findings from the world mental health surveys. Depression and anxiety. 2017;34(4):315–26. Epub 2016/12/07. doi: 10.1002/da.22579 27921352; PubMed Central PMCID: PMC5661943.

74. Stein DJ, Seedat S, Herman A, Moomal H, Heeringa SG, Kessler RC, et al. Lifetime prevalence of psychiatric disorders in South Africa. The British journal of psychiatry: the journal of mental science. 2008;192(2):112–7. Epub 2008/02/05. doi: 10.1192/bjp.bp.106.029280 18245026; PubMed Central PMCID: PMC2718689.

75. Herman AA, Stein DJ, Seedat S, Heeringa SG, Moomal H, Williams DR. The South African Stress and Health (SASH) study: 12-month and lifetime prevalence of common mental disorders. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 2009;99(5 Pt 2):339–44. Epub 2009/07/11. 19588796; PubMed Central PMCID: PMC3191537.

76. Williams DR, Gonzalez HM, Williams S, Mohammed SA, Moomal H, Stein DJ. Perceived discrimination, race and health in South Africa. Social science & medicine. 2008;67(3):441–52. doi: 10.1016/j.socscimed.2008.03.021 18486292; PubMed Central PMCID: PMC2643465.

77. Peltzer K, Pengpid S. High physical activity is associated with post-traumatic stress disorder among individuals aged 15 years and older in South Africa. The South African journal of psychiatry: SAJP: the journal of the Society of Psychiatrists of South Africa. 2019;25:1329. Epub 2019/11/21. doi: 10.4102/sajpsychiatry.v25i0.1329 31745437; PubMed Central PMCID: PMC6851996.

78. Neuner F, Pfeiffer A, Schauer-Kaiser E, Odenwald M, Elbert T, Ertl V. Haunted by ghosts: prevalence, predictors and outcomes of spirit possession experiences among former child soldiers and war-affected civilians in Northern Uganda. Social science & medicine. 2012;75(3):548–54. Epub 2012/05/15. doi: 10.1016/j.socscimed.2012.03.028 22580073.

79. Ertl V, Pfeiffer A, Schauer-Kaiser E, Elbert T, Neuner F. The challenge of living on: psychopathology and its mediating influence on the readjustment of former child soldiers. PloS one. 2014;9(7):e102786. Epub 2014/07/24. doi: 10.1371/journal.pone.0102786 25054324; PubMed Central PMCID: PMC4108375.

80. Rugema L, Mogren I, Ntaganira J, Krantz G. Traumatic episodes and mental health effects in young men and women in Rwanda, 17 years after the genocide. BMJ open. 2015;5(6):e006778. Epub 2015/06/26. doi: 10.1136/bmjopen-2014-006778 26109109; PubMed Central PMCID: PMC4480039.

81. Topper K, van Rooyen K, Grobler C, van Rooyen D, Andersson LM. Posttraumatic Stress Disorder and Barriers to Care in Eastern Cape Province, South Africa. Journal of traumatic stress. 2015;28(4):375–9. Epub 2015/08/14. doi: 10.1002/jts.22032 26271019.

82. Smit J, Myer L, Middelkoop K, Seedat S, Wood R, Bekker LG, et al. Mental health and sexual risk behaviours in a South African township: a community-based cross-sectional study. Public health. 2006;120(6):534–42. Epub 2006/05/11. doi: 10.1016/j.puhe.2006.01.009 16684549.

83. Asnakew S, Shumet S, Ginbare W, Legas G, Haile K. Prevalence of post-traumatic stress disorder and associated factors among Koshe landslide survivors, Addis Ababa, Ethiopia: a community-based, cross-sectional study. BMJ open. 2019;9(6):e028550. doi: 10.1136/bmjopen-2018-028550 31256034

84. Galea S, Rockers PC, Saydee G, Macauley R, Varpilah ST, Kruk ME. Persistent psychopathology in the wake of civil war: long-term posttraumatic stress disorder in Nimba County, Liberia. American journal of public health. 2010;100(9):1745–51. Epub 2010/07/17. doi: 10.2105/AJPH.2009.179697 20634461; PubMed Central PMCID: PMC2920997.

85. Machisa MT, Christofides N, Jewkes R. Mental ill health in structural pathways to women’s experiences of intimate partner violence. PloS one. 2017;12(4):e0175240. Epub 2017/04/07. doi: 10.1371/journal.pone.0175240 28384241; PubMed Central PMCID: PMC5383260.

86. Mollica R, Caspi-Yavin Y, Lavelle J. The Harvard Trauma Questionnaire (HTQ) manual: Cambodian, Laotian, and Vietnamese Versions. Torture Quarterly Journal on Rehabilitation of Torture Victims and Prevention of Torture. 1996;(Supplement 1):19–42.

87. Weathers F, Litz B, Herman D, Huska J, Keane T. The PTSD checklist-civilian version (PCL-C). Boston, MA: National Center for PTSD. 1994.

88. Brewin CR, Rose S, Andrews B, Green J, Tata P, McEvedy C, et al. Brief screening instrument for post-traumatic stress disorder. The British journal of psychiatry: the journal of mental science. 2002;181:158–62. Epub 2002/08/02. doi: 10.1017/s0007125000161896 12151288.

89. Davidson JR, Book SW, Colket JT, Tupler LA, Roth S, David D, et al. Assessment of a new self-rating scale for post-traumatic stress disorder. Psychological medicine. 1997;27(1):153–60. Epub 1997/01/01. doi: 10.1017/s0033291796004229 9122295.

90. Foa EB, Cashman L, Jaycox LH, Perry K. The validation of a self-report measure of posttraumatic stress disorder: The Posttraumatic Diagnostic Scale. Psychological assessment. 1997;9(4):445–51. http://dx.doi.org/10.1037/1040-3590.9.4.445.

91. Thoresen S, Tambs K, Hussain A, Heir T, Johansen VA, Bisson JI. Brief measure of posttraumatic stress reactions: impact of Event Scale-6. Social psychiatry and psychiatric epidemiology. 2010;45(3):405–12. Epub 2009/05/30. doi: 10.1007/s00127-009-0073-x 19479171.

92. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59 Suppl 20:22–33;quiz 4–57. Epub 1999/01/09. 9881538.

93. Foa EB, Riggs DS, Dancu CV, Rothbaum BO. Reliability and validity of a brief instrument for assessing post-traumatic stress disorder. 1993. 1994-15951-001.

94. Robins LN, Wing J, Wittchen HU, Helzer JE, Babor TF, Burke J, et al. The Composite International Diagnostic Interview. An epidemiologic Instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Archives of general psychiatry. 1988;45(12):1069–77. Epub 1988/12/01. doi: 10.1001/archpsyc.1988.01800360017003 2848472.

95. Ertl V, Pfeiffer A, Saile R, Schauer E, Elbert T, Neuner F. Validation of a mental health assessment in an African conflict population. Psychological assessment. 2010;22(2):318–24. Epub 2010/06/10. doi: 10.1037/a0018810 20528059.

96. Fodor KE, Pozen J, Ntaganira J, Sezibera V, Neugebauer R. The factor structure of posttraumatic stress disorder symptoms among Rwandans exposed to the 1994 genocide: A confirmatory factor analytic study using the PCL-C. J Anxiety Disord. 2015;32:8–16. Epub 2015/04/04. doi: 10.1016/j.janxdis.2015.03.001 25840139.

97. Betancourt TS, Brennan RT, Vinck P, VanderWeele TJ, Spencer-Walters D, Jeong J, et al. Associations between Mental Health and Ebola-Related Health Behaviors: A Regionally Representative Cross-sectional Survey in Post-conflict Sierra Leone. PloS medicine. 2016;13(8):e1002073. Epub 2016/08/10. doi: 10.1371/journal.pmed.1002073 27505186; PubMed Central PMCID: PMC4978463.

98. Gureje O, Lasebikan VO, Kola L, Makanjuola VA. Lifetime and 12-month prevalence of mental disorders in the Nigerian Survey of Mental Health and Well-Being. The British journal of psychiatry: the journal of mental science. 2006;188:465–71. Epub 2006/05/02. doi: 10.1192/bjp.188.5.465 16648534.

99. Ayazi T, Lien L, Eide AH, Ruom MM, Hauff E. What are the risk factors for the comorbidity of posttraumatic stress disorder and depression in a war-affected population? A cross-sectional community study in South Sudan. BMC psychiatry. 2012;12:175. Epub 2012/10/23. doi: 10.1186/1471-244X-12-175 23083301; PubMed Central PMCID: PMC3534332.

100. Kessler RC, Ustun TB. The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI). Int J Methods Psychiatr Res. 2004;13(2):93–121. Epub 2004/08/07. doi: 10.1002/mpr.168 15297906.

101. Morina N, Stam K, Pollet TV, Priebe S. Prevalence of depression and posttraumatic stress disorder in adult civilian survivors of war who stay in war-afflicted regions. A systematic review and meta-analysis of epidemiological studies. Journal of affective disorders. 2018;239:328–38. Epub 2018/07/22. doi: 10.1016/j.jad.2018.07.027 30031252.

102. World Health Organization. mhGAP in Ethiopia: Proof of Concept. 2013. [cited 27 Apr 2020]. Available from: https://www.who.int/mental_health/mhgap/mhgap_ethiopia_proof_of_concept_2013.pdf.

103. Bolton P, Wilk CM, Ndogoni L. Assessment of depression prevalence in rural Uganda using symptom and function criteria. Social psychiatry and psychiatric epidemiology. 2004;39(6):442–7. Epub 2004/06/19. doi: 10.1007/s00127-004-0763-3 15205728.

104. Bolton P, Neugebauer R, Ndogoni L. Prevalence of depression in rural Rwanda based on symptom and functional criteria. The Journal of nervous and mental disease. 2002;190(9):631–7. Epub 2002/10/03. doi: 10.1097/00005053-200209000-00009 12357098.

105. Mollica RF, McInnes K, Sarajlic N, Lavelle J, Sarajlic I, Massagli MP. Disability associated with psychiatric comorbidity and health status in Bosnian refugees living in Croatia. JAMA: the journal of the American Medical Association. 1999;282(5):433–9. Epub 1999/08/12. doi: 10.1001/jama.282.5.433 10442658.

106. McLaughlin KA, Koenen KC, Friedman MJ, Ruscio AM, Karam EG, Shahly V, et al. Subthreshold posttraumatic stress disorder in the world health organization world mental health surveys. Biological psychiatry. 2015;77(4):375–84. Epub 2014/05/21. doi: 10.1016/j.biopsych.2014.03.028 24842116; PubMed Central PMCID: PMC4194258.

107. Michalopoulos LM, Meinhart M, Yung J, Barton SM, Wang X, Chakrabarti U, et al. Global Posttrauma Symptoms: A Systematic Review of Qualitative Literature. Trauma, violence & abuse. 2018:1524838018772293. Epub 2018/04/28. doi: 10.1177/1524838018772293 29699456.

108. First M, B., Spitzer R, L., Gibbon M, Williams Janet BW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-patient Edition (SCID-I/NP). New York, NY: New York State Psychiatric Institute, 2002.

109. Madigoe T, Burns J, Zhang M, Subramaney U. Towards a culturally appropriate trauma assessment in a South African Zulu community. Psychol Trauma. 2017;9(3):274–81. Epub 2017/05/02. doi: 10.1037/tra0000231 28459270.

110. Haroz EE, Bass JK, Lee C, Murray LK, Robinson C, Bolton P. Adaptation and testing of psychosocial assessment instruments for cross-cultural use: an example from the Thailand Burma border. BMC psychology. 2014;2(1):31. Epub 2015/02/17. doi: 10.1186/s40359-014-0031-6 25685351; PubMed Central PMCID: PMC4317135.

111. Hyman SE. The Unconscionable Gap Between What We Know and What We Do. Science Translational Medicine. 2014;6(253):253cm9. doi: 10.1126/scitranslmed.3010312 25210058

112. Mental health atlas 2017. Geneva: World Health Organization; 2018. Licence: CC BY-NC-SA 3.0 IGO.

113. van Aert RCM, Wicherts JM, van Assen MALM. Publication bias examined in meta-analyses from psychology and medicine: A meta-meta-analysis. PloS one. 2019;14(4):e0215052–e. doi: 10.1371/journal.pone.0215052 30978228.

114. The World Health Organization. Download the WHO WMH-CIDI Instruments 2017 [cited 2019 March 7]. Available from: https://www.hcp.med.harvard.edu/wmhcidi/download-the-who-wmh-cidi-instruments/.

115. Jewkes R, Abrahams N. The epidemiology of rape and sexual coercion in South Africa: an overview. Social science & medicine. 2002;55(7):1231–44. Epub 2002/10/09. doi: 10.1016/s0277-9536(01)00242-8 12365533.

116. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-IV). 4th ed. Washington DC: American Psychiatric Association; 2000.

117. van Ommeren M, Sharma B, Makaju R, Thapa S, de Jong J. Limited Cultural Validity of the Composite International Diagnostic Interview’s Probe Flow Chart. Transcult Psychiatry. 2000;37(1):119–29. https://doi.org/10.1177/136346150003700107.

118. Gelaye B, Williams MA, Lemma S, Deyessa N, Bahretibeb Y, Shibre T, et al. Diagnostic validity of the composite international diagnostic interview (CIDI) depression module in an East African population. Int J Psychiatry Med. 2013;46(4):387–405. Epub 2013/01/01. doi: 10.2190/PM.46.4.e 24922989; PubMed Central PMCID: PMC4058648.

119. Beals J, Manson SM, Whitesell NR, Mitchell CM, Novins DK, Simpson S, et al. Prevalence of major depressive episode in two American Indian reservation populations: unexpected findings with a structured interview. The American journal of psychiatry. 2005;162(9):1713–22. Epub 2005/09/02. doi: 10.1176/appi.ajp.162.9.1713 16135632.

120. Scorza P, Masyn K, Salomon JA, Betancourt TS. The impact of measurement differences on cross-country depression prevalence estimates: A latent transition analysis. PloS one. 2018;13(6):e0198429. Epub 2018/06/08. doi: 10.1371/journal.pone.0198429 29879167; PubMed Central PMCID: PMC5991686.

121. Lund C, Tomlinson M, De Silva M, Fekadu A, Shidhaye R, Jordans M, et al. PRIME: a programme to reduce the treatment gap for mental disorders in five low- and middle-income countries. PLoS medicine. 2012;9(12):e1001359. Epub 2013/01/10. doi: 10.1371/journal.pmed.1001359 23300387; PubMed Central PMCID: PMC3531506.

122. World Health Organization. mhGAP intervention guide for mental, neurological and substance use disorders in non-specialized health settings: Mental Health Gap Action Programme (mhGAP). Geneva: World Health Organization; 2010.

123. World Health Organization and United Nations High Commissioner for Refugees. mhGAP Humanitarian Intervention Guide (mhGAP-HIG): clinical management of mental, neurological and substance use conditions in humanitarian emergencies (Version 1.0). Geneva: 2015.

124. Johnson K, Scott J, Rughita B, Kisielewski M, Asher J, Ong R, et al. Association of sexual violence and human rights violations with physical and mental health in territories of the Eastern Democratic Republic of the Congo. JAMA: the journal of the American Medical Association. 2010;304(5):553–62. doi: 10.1001/jama.2010.1086 20682935.

125. Jenkins R, Othieno C, Omollo R, Ongeri L, Sifuna P, Mboroki JK, et al. Probable Post Traumatic Stress Disorder in Kenya and Its Associated Risk Factors: A Cross-Sectional Household Survey. Int J Environ Res Public Health. 2015;12(10):13494–509. Epub 2015/10/31. doi: 10.3390/ijerph121013494 26516877; PubMed Central PMCID: PMC4627045.

126. Pham PN, Weinstein HM, Longman T. Trauma and PTSD symptoms in Rwanda: implications for attitudes toward justice and reconciliation. JAMA: the journal of the American Medical Association. 2004;292(5):602–12. doi: 10.1001/jama.292.5.602 15292086.

127. Williams DR, Herman A, Stein DJ, Heeringa SG, Jackson PB, Moomal H, et al. Twelve-month mental disorders in South Africa: prevalence, service use and demographic correlates in the population-based South African Stress and Health Study. Psychological medicine. 2008;38(2):211–20. Epub 2007/10/02. doi: 10.1017/S0033291707001420 17903333; PubMed Central PMCID: PMC2718686.

128. Myer L, Stein DJ, Grimsrud AT, Herman A, Seedat S, Moomal H, et al. DSM-IV-defined common mental disorders: association with HIV testing, HIV-related fears, perceived risk and preventive behaviours among South African adults. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 2009;99(5 Pt 2):396–402. 19588804.

129. Dückers MLA, Alisic E, Brewin CR. A vulnerability paradox in the cross-national prevalence of post-traumatic stress disorder. British Journal of Psychiatry. 2018;209(4):300–5. Epub 01/02. doi: 10.1192/bjp.bp.115.176628

130. Ayazi T, Lien L, Eide A, Swartz L, Hauff E. Association between exposure to traumatic events and anxiety disorders in a post-conflict setting: a cross-sectional community study in South Sudan. BMC psychiatry. 2014;14:6. Epub 2014/01/15. doi: 10.1186/1471-244X-14-6 24410951; PubMed Central PMCID: PMC3893536.

131. Ng LC, Lopez B, Pritchard M, Deng D. Posttraumatic stress disorder, trauma, and reconciliation in South Sudan. Social psychiatry and psychiatric epidemiology. 2017;52(6):705–14. Epub 2017/04/13. doi: 10.1007/s00127-017-1376-y 28401274; PubMed Central PMCID: PMC5510537.

132. Roberts B, Damundu EY, Lomoro O, Sondorp E. Post-conflict mental health needs: a cross-sectional survey of trauma, depression and associated factors in Juba, Southern Sudan. BMC psychiatry. 2009;9:7. Epub 2009/03/06. doi: 10.1186/1471-244X-9-7 19261192; PubMed Central PMCID: PMC2656503.

133. Mugisha J, Muyinda H, Wandiembe P, Kinyanda E. Prevalence and factors associated with Posttraumatic Stress Disorder seven years after the conflict in three districts in northern Uganda (The Wayo-Nero Study). BMC psychiatry. 2015;15:170. Epub 2015/07/25. doi: 10.1186/s12888-015-0551-5 26205192; PubMed Central PMCID: PMC4513792.

134. Mugisha J, Muyinda H, Malamba S, Kinyanda E. Major depressive disorder seven years after the conflict in northern Uganda: burden, risk factors and impact on outcomes (The Wayo-Nero Study). BMC psychiatry. 2015;15:48. Epub 2015/04/17. doi: 10.1186/s12888-015-0423-z 25881310; PubMed Central PMCID: PMC4376071.

135. Mugisha J, Muyinda H, Kagee A, Wandiembe P, Mpugu SK, Vancampfort D, et al. Prevalence of suicidal ideation and attempt: associations with psychiatric disorders and HIV/AIDS in post-conflict Northern Uganda. Afr Health Sci. 2016;16(4):1027–35. Epub 2017/05/10. doi: 10.4314/ahs.v16i4.20 28479896; PubMed Central PMCID: PMC5398450.

136. Pham PN, Vinck P, Stover E. Returning home: forced conscription, reintegration, and mental health status of former abductees of the Lord's Resistance Army in northern Uganda. BMC psychiatry. 2009;9:23. Epub 2009/05/19. doi: 10.1186/1471-244X-9-23 19445689; PubMed Central PMCID: PMC2693494.

137. Vinck P, Pham PN, Stover E, Weinstein HM. Exposure to war crimes and implications for peace building in northern Uganda. JAMA: the journal of the American Medical Association. 2007;298(5):543–54. doi: 10.1001/jama.298.5.543 17666675.

138. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM). Washington, DC: American Psychiatric Association. 1994.

139. World Health Organization. ICD-10: international statistical classification of diseases and related health problems: tenth revision. 2nd ed: World Health Organization; 2004.

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