Autoři: Chanchal Chandramouli aff001; Wan Ting Tay aff001; Nurul Sahiddah Bamadhaj aff001; Jasper Tromp aff001; Tiew-Hwa Katherine Teng aff001; Jonathan J. L. Yap aff001; Michael R. MacDonald aff003; Chung-Lieh Hung aff004; Koen Streng aff002; Ajay Naik aff005; Gurpreet Singh Wander aff006; Jitendra Sawhney aff007; Lieng Hsi Ling aff008; A. Mark Richards aff008; Inder Anand aff009; Adriaan A. Voors aff002; Carolyn S. P. Lam aff001; Působiště autorů: National Heart Centre Singapore, Singapore, Singapore aff001; University Medical Center Groningen, Groningen, Netherlands aff002; Changi General Hospital, Singapore, Singapore aff003; MacKay Memorial Hospital, Taipei, Taiwan aff004; CIMS Hospital, Ahmedabad, Gujarat, India aff005; Dayanand Medical College and Hospital, Ludhiana, Punjab, India aff006; Sir Gangaram Hospital, New Delhi, India aff007; Cardiovascular Research Institute, Singapore, Singapore aff008; Veterans Affairs Medical Center, Minneapolis, Minnesota, United States of America aff009; Duke-NUS Medical School, Singapore, Singapore aff010 Vyšlo v časopise: Association of obesity with heart failure outcomes in 11 Asian regions: A cohort study. PLoS Med 16(9): e32767. doi:10.1371/journal.pmed.1002916 Kategorie: Research Article doi: https://doi.org/10.1371/journal.pmed.1002916
Asians are predisposed to a lean heart failure (HF) phenotype. Data on the ‘obesity paradox’, reported in Western populations, are scarce in Asia and have only utilised the traditional classification of body mass index (BMI). We aimed to investigate the association between obesity (defined by BMI and abdominal measures) and HF outcomes in Asia.
Utilising the Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry (11 Asian regions including Taiwan, Hong Kong, China, India, Malaysia, Thailand, Singapore, Indonesia, Philippines, Japan, and Korea; 46 centres with enrolment between 1 October 2012 and 6 October 2016), we prospectively examined 5,964 patients with symptomatic HF (mean age 61.3 ± 13.3 years, 26% women, mean BMI 25.3 ± 5.3 kg/m2, 16% with HF with preserved ejection fraction [HFpEF; ejection fraction ≥ 50%]), among whom 2,051 also had waist-to-height ratio (WHtR) measurements (mean age 60.8 ± 12.9 years, 24% women, mean BMI 25.0 ± 5.2 kg/m2, 7% HFpEF). Patients were categorised by BMI quartiles or WHtR quartiles or 4 combined groups of BMI (low, <24.5 kg/m2 [lean], or high, ≥24.5 kg/m2 [obese]) and WHtR (low, <0.55 [thin], or high, ≥0.55 [fat]). Cox proportional hazards models were used to examine a 1-year composite outcome (HF hospitalisation or mortality). Across BMI quartiles, higher BMI was associated with lower risk of the composite outcome (ptrend < 0.001). Contrastingly, higher WHtR was associated with higher risk of the composite outcome. Individuals in the lean-fat group, with low BMI and high WHtR (13.9%), were more likely to be women (35.4%) and to be from low-income countries (47.7%) (predominantly in South/Southeast Asia), and had higher prevalence of diabetes (46%), worse quality of life scores (63.3 ± 24.2), and a higher rate of the composite outcome (51/232; 22%), compared to the other groups (p < 0.05 for all). Following multivariable adjustment, the lean-fat group had higher adjusted risk of the composite outcome (hazard ratio 1.93, 95% CI 1.17–3.18, p = 0.01), compared to the obese-thin group, with high BMI and low WHtR. Results were consistent across both HF subtypes (HFpEF and HF with reduced ejection fraction [HFrEF]; pinteraction = 0.355). Selection bias and residual confounding are potential limitations of such multinational observational registries.
In this cohort of Asian patients with HF, the ‘obesity paradox’ is observed only when defined using BMI, with WHtR showing the opposite association with the composite outcome. Lean-fat patients, with high WHtR and low BMI, have the worst outcomes. A direct correlation between high WHtR and the composite outcome is apparent in both HFpEF and HFrEF.
Asian Sudden Cardiac Death in HF (ASIAN-HF) Registry ClinicalTrials.gov Identifier: NCT01633398
Adipose tissue – Asia – Body Mass Index – Ejection fraction – Fats – Heart failure – Obesity
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