PLOS Genetics - Číslo 5/2013

Review

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Global Properties and Functional Complexity of Human Gene Regulatory Variation

Perspective

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Side Effects: Substantial Non-Neutral Evolution Flanking Regulatory Sites
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From Paramutation to Paradigm

Research Article

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Functional Elements Are Embedded in Structurally Constrained Sequences
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Using Extended Genealogy to Estimate Components of Heritability for 23 Quantitative and Dichotomous Traits
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Female Bias in and Regulation by the Histone Demethylase KDM6A
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ATM–Dependent MiR-335 Targets CtIP and Modulates the DNA Damage Response
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HDAC7 Is a Repressor of Myeloid Genes Whose Downregulation Is Required for Transdifferentiation of Pre-B Cells into Macrophages
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The Majority of Primate-Specific Regulatory Sequences Are Derived from Transposable Elements
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Identification of Meiotic Cyclins Reveals Functional Diversification among Plant Cyclin Genes
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EGL-13/SoxD Specifies Distinct O and CO Sensory Neuron Fates in
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Congruence of Additive and Non-Additive Effects on Gene Expression Estimated from Pedigree and SNP Data
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Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression
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From Mouse to Human: Evolutionary Genomics Analysis of Human Orthologs of Essential Genes
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Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration
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Duplication and Retention Biases of Essential and Non-Essential Genes Revealed by Systematic Knockdown Analyses
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Strong Purifying Selection at Synonymous Sites in
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, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein
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Chromosome Movements Promoted by the Mitochondrial Protein SPD-3 Are Required for Homology Search during Meiosis
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The Secretory Pathway Calcium ATPase PMR-1/SPCA1 Has Essential Roles in Cell Migration during Embryonic Development
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The Genomic Signature of Crop-Wild Introgression in Maize
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CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point
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Distinct Translational Control in CD4 T Cell Subsets
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DNA Binding of the Cell Cycle Transcriptional Regulator GcrA Depends on N6-Adenosine Methylation in and Other
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RNA–Mediated Epigenetic Heredity Requires the Cytosine Methyltransferase Dnmt2
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Bck2 Acts through the MADS Box Protein Mcm1 to Activate Cell-Cycle-Regulated Genes in Budding Yeast
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Loss of Expression and Promoter Methylation of SLIT2 Are Associated with Sessile Serrated Adenoma Formation
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Attachment Site Selection and Identity in Bxb1 Serine Integrase-Mediated Site-Specific Recombination
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Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway
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Genome-Wide Analysis in German Shepherd Dogs Reveals Association of a Locus on CFA 27 with Atopic Dermatitis
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Liver X Receptors Protect from Development of Prostatic Intra-Epithelial Neoplasia in Mice
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Chromosomal Organization and Segregation in
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A Statistical Framework for Joint eQTL Analysis in Multiple Tissues
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Cell Polarity and Patterning by PIN Trafficking through Early Endosomal Compartments in
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High-Resolution Transcriptome Maps Reveal Strain-Specific Regulatory Features of Multiple Isolates
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Encodes CDF Transporters That Excrete Zinc from Intestinal Cells of and Act in a Parallel Negative Feedback Circuit That Promotes Homeostasis
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Neuropeptides Function in a Homeostatic Manner to Modulate Excitation-Inhibition Imbalance in
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A Compendium of Nucleosome and Transcript Profiles Reveals Determinants of Chromatin Architecture and Transcription
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Wnt Signaling Regulates the Lineage Differentiation Potential of Mouse Embryonic Stem Cells through Tcf3 Down-Regulation
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Filamin and Phospholipase C-ε Are Required for Calcium Signaling in the Spermatheca
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The Specificity and Flexibility of L1 Reverse Transcription Priming at Imperfect T-Tracts
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Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations
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Implicates Tyrosine-Sulfated Peptide Signaling in Susceptibility and Resistance to Root Infection
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Clathrin and AP2 Are Required for Phagocytic Receptor-Mediated Apoptotic Cell Clearance in
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Genome-Wide Identification of Regulatory RNAs in the Human Pathogen

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