“Shadow cell” diferenciácia v endometrioidných karcinómoch tela maternice. Jej častý výskyt a pozitivita na beta-katenín

English version

Autoři: Michal Zámečník ^1,2; Pavel Bartoš ³; Peter Kaščák ^4,5
Působiště autorů: AGEL, a. s., Laboratory of Surgical Pathology, Nový Jičín, Czech Republic ¹; Medirex Group Academy, n. o., Bratislava, Slovak Republic ²; Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Novy Jičín, Czech Republic ³; Department of Obstetrics and Gynecology, Regional Hospital, Trenčín, Slovak Republic ⁴; Faculty of Health, Alexander Dubček University, Trenčín, Slovak Republic ⁵
Vyšlo v časopise: Čes.-slov. Patol., 51, 2015, No. 3, p. 123-126
Kategorie: Původní práce

Souhrn

“Shadow cell” diferenciácia (SCD) je typická pre pilomatrixómy a iné trichogénne kožné tumory. Zriedka bola popísaná v extrakutánnych léziach ako sú gonadálny teratóm, kraniofaryngeóm, odontogénna cysta, niektoré viscerálne karcinómy (pľúc, žlčníka, močového mechúra, hrubého čreva, maternice a vaječníka). V bioptickej praxi sme si všimli, že “shadow” bunky nie sú príliš raritné v endometrioidných karcinómoch dutiny maternice. Pre presnejšie zistenie ich výskytu sme vyšetrili 59 konzekutívnych prípadov endometrioidného karcinómu (hysteroskopické biopsie a kyretáže). SCD sme našli v 9 prípadoch (15,3 %). Vek pacientiek a FIGO grading tumorov sa nelíšili od iných endometrioidných karcinómov. Imunohistochemicky bola u všetkých tumorov so SCD zistená jadrová pozitivita beta-katenínu viazaná na oblasť skvamóznej a “shadow cell” diferenciácie, čo suponuje úlohu mutácie príslušného génu v tumor-genéze (podobne ako u pilomatrixómu) a úlohu nukleárnej akumulácie beta-katenínu v trans-diferenciácii od glandulárneho smerom k skvamóznemu a “shadow cell” fenotypu. Vzhľadom k častému výskytu SCD v endometrioidnom karcinóme môže byť jej nález napomocný pri diagnostike tohto tumoru.

Kľúčové slová:
beta-katenín –⁠ endometrioidný karcinóm –⁠ maternica –⁠ “shadow cell” differenciácia

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