Introduction to the role of hypofractionated gamma knife therapy in brain metastases

Česká verze

Authors: T. Chytka ¹; R. Liščák ¹; P. Štursa ²
Authors place of work: Oddělení stereotaktické a radiační, neurochirurgie, Nemocnice, na Homolce, Praha ¹; Radiodiagnostické oddělení, Nemocnice na Homolce, Praha ²
Published in the journal: Cesk Slov Neurol N 2025; 88(3): 153-159
Category: Přehledný referát
doi: https://doi.org/10.48095/cccsnn2025153

Summary

One single irradiation using the gamma knife has its clear radiobiological advantages, but also limitations, most often due to the size of the tumor. Radiosurgical treatment can then be divided into several sessions, with each session interrupted by a sufficiently long-term interval depending on the treatment regimen. The latest technical development of the gamma knife has made it possible to expand the indications using integrated cone beam CT and non-invasive fixation with a thermoplastic mask to indications that are not suitable for single irradiation; these can be treated hypofractionally by utilizing the main added benefit of the gamma knife, i.e., submillimeter accuracy of irradiation, high conformity of the applied dose, and steep gradient of the dose gradient beyond the tumor boundary. However, information on hypofractionation irradiation schemes is limited and optimal recommendations are still being sought. Their evaluation is therefore a very current topic.

Keywords:

Gamma Knife radiosurgery – brain metastases – dose-stage gamma knife radiosurgery – hypofractionated gamma knife radiosurgery

Zdroje

Literatura

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