Vztah mezi endometriózou a polymorfi zmem genu pro vaspin RS2236242

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Autoři: Huriye Ezveci ¹ ; Ayşe Gül Kebapcılar ²
Působiště autorů: Department of Obstetrics and Gynecology, Division of Perinatology, Necmettin Erbakan University Medical School of Meram, Konya, Turkey ¹; Department of Obstetrics and Gynecology, Medova Hospital, Konya, Turkey ²
Vyšlo v časopise: Ceska Gynekol 2024; 89(5): 385-390
Kategorie: Původní práce
doi: https://doi.org/10.48095/cccg2024385

Souhrn

Cíl: Cílem této studie je prozkoumat vztah mezi endometriózou a polymorfizmem genu pro vaspin RS2236242. Materiál a metody: Tato prospektivní průřezová studie případů a kontrol zahrnovala pacientky s endometriózou 4. stupně a kontrolní skupinu zdravých žen. V těchto studijních skupinách byl hodnocen polymorfizmus genu pro vaspin RS2236242. Výsledky: Studie se zúčastnilo 38 jedinců s endometriózou a 17 žen z kontrolní skupiny. Skupina žen s endometriózou vykazovala podobné charakteristiky jako kontrolní skupina, pokud jde o pohlaví, index tělesné hmotnosti (BMI) a věk (průměrný věk kontroly: 29,6 ± 4,62 let; BMI: 24,02 kg/m²; průměrný věk žen s endometriózou: 30,4 ± 5,01 let; BMI: 23,63 kg/m²). Podle statistické analýzy byl významný rozdíl v distribuci genotypu polymorfizmu pro vaspin RS2236242 mezi ženami s endometriózou a kontrolami (p = 0,027). Genotyp AT způsoboval endometriózu s vyšší pravděpodobností než genotyp TT (OR 2,474; 95% CI 0,668–9,169), když jsme sledovali poměr relativního rizika endometriózy genotypů. Mezi případy a kontrolami byly pozorovány signifikantní rozdíly v celkové četnosti genotypů AT a TT (OR 2,31; 95% CI 0,86–0,92; p = 0,03). Genotypy AT a TT byly spojeny s rizikem endometriózy. Závěr: Byla pozorována významná souvislost mezi polymorfizmem pro vaspin RS2274907 A/T a pravděpodobností rozvoje endometriózy.

Klíčová slova:

Endometrióza – SNP – vaspin RS2274907 – izolace DNA

Zdroje

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Author contributions

HE: project development, data managament, manuscript writing

AK: data managament, manuscript editing, protocol and project development

ORCID authors

H. Ezveci 0000-0002-7626-5799

A. G. Kebapcılar 0000-0003-4576-3434

Submitted/Doručeno: 20. 5. 2024

Accepted/Přijato: 23. 6. 2024

Huriye Ezveci, MD

Hocacihan neighborhood

Abdulhamidhan Street. No: 3

Selçuklu/Konya