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Guava leaf extract and polyvinylpyrrolidone hydrogel for rabbit oral wounds


Autoři: I. G. A. B. Jayaningrum 1;  A. R. R. Hariantana Hamid 1;  I. G. P. Hendra Sanjaya 1;  G. W. Samsarga 2;  I. W. Niryana 3;  I. M. Darmajaya 4;  S. Diwyani Sudarsa 2;  A. Lestari Suyata 2
Působiště autorů: Division of Plastic Surgery Reconstruction and Aesthetic, IGNG Ngoerah General Hospital, Denpasar, Bali 1;  Division of Plastic Surgery Reconstruction and Aesthetic, Udayana Hospital, Denpasar, Bali 2;  Department of Neurosurgery, IGNG Ngoerah General Hospital, Denpasar, Bali 3;  Department of Pediatric Surgery, IGNG Ngoerah General Hospital, Denpasar, Bali 4
Vyšlo v časopise: ACTA CHIRURGIAE PLASTICAE, 67, 3, 2025, pp. 180-188
doi: https://doi.org/10.48095/ccachp2025180


Zdroje

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2. Khan TU., Rahar S., Khan ZA., et al. Etiology and pattern of maxillofacial trauma. [online]. Available from: https: //pmc.ncbi.nlm.nih.gov/articles/PMC9522305/.

3. Singh V., Malkunje L., Mohammad S., et al. The maxillofacial injuries: a study. [online]. Available from: https: //pmc.ncbi.nlm.nih.gov/articles/PMC3700151/.

4. Esmaeelinejad M. Maxillofacial fractures: from diagnosis to treatment. [online]. Available from: https: //www.intechopen.com/chapters/60520.

5. Yadav A. Principles of internal fixation in maxillofacial surgery. [online]. Available from: https: //link.springer.com/chapter/10.1007/ 978-981-15-1346-6_51.

6. Oksa M., Haapanen A., Marttila E., et al. Postoperative wound dehiscence in mandibular fractures. Acta Odontol Scand. 2023; 81 (7): 555–561.

17. Kumar JN., Ravi P. Postoperative care of the maxillofacial surgery patient. [online]. Available from: https: //pmc.ncbi.nlm.nih.gov/articles/PMC7882239/.

18. Espinosa MC., Hohman MH., Sivam S. Oral and maxillofacial surgery, facial laceration repair. [online]. Available from: https: //www.ncbi.nlm.nih.gov/books/NBK570584/.

9. Budovsky A., Yarmolinsky L., Ben-Shabat S. Effect of medicinal plants on wound healing. Wound Repair Regen. 2015, 23 (2): 171–183.

10. Carolino MV., Purnamasari L., Flores Dela Cruz J. The antibacterial properties of Psidium guajava leaf extract as a wound healing agent of laboratory animals: a review. [online]. Available from: https: //biotropika.ub.ac.id/index.php/biotropika/article/view/1313/0.

11. Buchsel PC. Polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair): a bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions. Expert Opin Drug Metab Toxicol. 2008, 4 (11): 1449–1454.

12. Roman R. Fibroblasts –⁠ warriors at the intersection of wound healing and immunomodulation. Biomolecules. 2023, 13 (6): 945.

13. Stunova A., Vistejnova L. Dermal fibroblasts: A heterogeneous population with regulatory functions in wound healing. Cytokine & Growth Factor Rev. 2018, 39 : 137–150.

14. Foster DS., Januszyk M., Yost KE., et al. Integrated spatial multiomics reveals fibroblast fate during tissue repair. Proc Natl Acad Sci USA. 2021, 118 (41): e2110025118.

15. Sutrisno E., Susilawati E., Herdiana GB., et al. Gel formulations of guava leaves (Psidium guajava L) ethanol extract as a wound healing of burns in rabbits. [online]. Available from: https: //journal.rescollacomm.com/index.php/ijrcs/article/view/626.

16. Dvorak HF. Reconciling VEGF with VPF: The importance of increased vascular permeability for stroma formation in tumors, healing wounds, and chronic inflammation. Front Cell Dev Biol. 2021, 9 : 660609.

17. Maigoda AR., Refdanita S., Abidin Z. Collagen synthesis in wound healing accelerated by herbal gel formulation. Int J Biol Macromol. 2022; 194 : 567–576.

18. Yang L., Zhang L., Hu J., et al. Promote anti-inflammatory and angiogenesis using a hyaluronic acid-based hydrogel with miRNA-laden nanoparticles for chronic diabetic wound treatment. Int J Biol Macromol. 2021; 166 : 166–178.

19. Ekom SE., Tamokou J-DD. Methanol leaves extract of Psidium guajava Linn. exhibited antibacterial and wound healing activities. [online]. Available from: https: //www.researchgate.net/publication/326673330_Methanol_Leaves_Extract_of_Psidium_guajava_Linn_Exhibited_Antibacterial_and_Wound_Healing_ Activities.

20. Hakim RF., Fakhrurrazi F., Zamzami FS. Comparison of the effect of guava (Psidium guajava L.) leaf extract with polyvinylpyrrolidone-sodium hyaluronate on the number of fibroblasts (study on white rats Rattus norvegicus). [online]. Available from: https: //www.researchgate.net/publication/372779522_Comparison_of_the_effect_of_guava_psidium_guajava_ l_Leaf_extract_x_withpolyvinylpyrrolidone-sodium_hyaluronate_on_the_number_fibroblasts_study_on_white_rats_rattus_norvegicus

21. Naseer S., Hussain S., Naeem N., et al. The phytochemistry and medicinal value of Psidium guajava (guava). [online]. Available from: https: //clinphytoscience.springeropen.com/articles/10.1186/s40816-018-0093-8

22. Delorino SB., Ogalesco ML., Rebadulla KR., et al. Wound healing efficacy of guava leaf extract. [online]. Available from: https: //journaljpri.com/index.php/JPRI/article/view/1882/ 3772.

23. Ahmad A., Nawaz MI. Molecular mechanism of VEGF and its role in pathological angiogenesis. J Cell Biochem. 2022, 123 (12): 1938–1965.

24. Das A., Abas M., Biswas N., et al. A modified collagen dressing induces transition of inflammatory to reparative phenotype of wound macrophages. Sci Rep. 2019, 9 : 14688.

I Gusti Ayu Agung Bella Jayaningrum

Imam Bonjol Street, Rahayu Alley

Denpasar, Bali, Indonesia

bellajayaningrumspbp@gmail.com

Submitted: 31. 3. 2025

Accepted: 31. 10. 2025

Štítky
Chirurgie plastická Ortopedie Popáleninová medicína Traumatologie

Článek vyšel v časopise

Acta chirurgiae plasticae

Číslo 3

2025 Číslo 3
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