DESIGN, MANUFACTURE AND TESTING OF RABBIT IMPLANTATION STRUCTURES FOR PRECLINICAL EXAMINATIONS


Autoři: Lukáš Mitrík ;  Marianna Trebuňová ;  Radovan Hudák ;  Marek Schnitzer ;  Jozef Živčák
Vyšlo v časopise: Lékař a technika - Clinician and Technology No. 1, 2019, 49, 11-15
Kategorie: Original research

Souhrn

The aim of this study was to develop a methodology of preclinical animal testing in case studies for implants with PEEK material and its derivatives with possible use for other materials. In the theoretical part, the study deals with the analysis of the current situation in the area of preclinical animal testing, especially in the field of implantology. Based on this analysis, the test implant structures were prepared at the workplace, which were subsequently inserted into appropriate rabbit individuals by surgical intervention in case studies. These case studies serve to create a comprehensive test methodology for animal preclinical tests within a statistically relevant animal sample for the needs of subsequent clinical testing and certification of the biomaterial used.

Klíčová slova:

PEEK – animal – implants – osteointegration – ceramics


Zdroje
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  4. Durham III JW, Montelongo SA, Ong JL, Guda T, Allen MJ, Rabiei A. Hydroxyapatite coating on PEEK implants: Bio-mechanical and histological study in a rabbit model. Materials Science and Engineering: C. 2016 Nov 1;68:723-31.
  5. Walsh WR, Pelletier MH, Bertollo N, Christou C, Tan C. Does PEEK/HA enhance bone formation compared with PEEK in a sheep cervical fusion model? Clinical Orthopaedics and Related Research. 2016 Nov 1;474(11):2364-72.
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Štítky
Biomedicína

Článek vyšel v časopise

Lékař a technika

Číslo 1

2019 Číslo 1

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