LDL-cholesterol (LDL-C), vypočíst, změřit, nahradit?

LDL-cholesterol (LDL-C), calculate, measure, replace?

In 2025, several comprehensive educational communications were published on the practical aspects of lipid-related international recommendations, intended for application in the routine activities of clinical laboratories. The first comes from ADLM -⁠ Association of Diagnostics and Laboratory Medicine, the second communication is from HEART UK and ALM (Association of Laboratory Medicine) UK. Both publications emphasize unresolved analytical issues in LDL-C determination methods, particularly the interference caused by elevated triglyceride concentrations and the resulting accuracy of diagnostic decision limits for dyslipidemia. Both works explicitly favor the calculation of LDL-C over its direct measurement, especially in American and British recommendations. This is contrary to common practice in our country and in Europe and therefore deserves increased attention.

Keywords:

dyslipidemia – LDL-C – guidelines ESC/EAT