Souvislost mezi hladinou volného trijodtyroninu v séru a skóre Mini-Mental State Examination po prodělané akutní ischemické CMP

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Autoři: S. Taroza; J. Burkauskas; A. Podlipskyté; N. Mickuviené
Působiště autorů: Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania
Vyšlo v časopise: Cesk Slov Neurol N 2023; 86(1): 74-81
Kategorie: Původní práce
doi: https://doi.org/10.48095/cccsnn202374

Souhrn

Cíl: Cílem této studie bylo určit souvislost mezi hormony produkovanými hypotalamo-hypofyzárně-tyroidní (tyroidní) osou (thyroid axis produced hormones; TAPH) a kognitivním stavem po prodělané akutni ischemické CMP (acute ischemic stroke; AIS). Materiál a metody: U jedinců s AIS z tří různých výzkumných a klinických center byla stanovena hladina TAPH v séru, vč. tyreostimulačního hormonu, volného tyroxinu a volného trijodtyroninu (FT3), a to po přijetí pacienta a před jeho propuštěním. Kognitivní funkce byly hodnoceny během akutní ubakutní fáze AIS pomocí Mini-Mental State Examination (MMSE). Výsledky: Byla získána data týkající se 194 jedinců s AIS v akutní fázi a 89 jedinců s AIS v subakutní fázi. Během akutní fáze AIS byla nezávislou determinantou kognitivního stavu hladina FT3 (R2 = 0,016; p = 0,017). Během subakutní fáze AIS nebyly zjištěny žádné nezávislé asociace mezi změřenými hladinami hormonů v séru a MMSE. Závěr: Hladina FT3 v séru změřená při přijetí pacienta s AIS v akutní fázi může predikovat jeho kognitivní stav hodnocený pomocí MMSE.

Klíčová slova:

ischemická cévní mozková příhoda – tyreostimulační hormon – volný trijodotyronin – volný tyroxin – kognitivní stav

Zdroje

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