Nejvýznamnější markery receptivity endometria


Autoři: N. Kushniruk ;  T. Fait
Působiště autorů: Department of Obstetrics and Gyneacology, 1st Faculty of Medicine, Charles University, General Faculty Hospital, Prague ;  Head of Department prof. MUDr. A. Martan, DrSc.
Vyšlo v časopise: Čes. Gynek.2014, 79, č. 4 s. 269-275

Souhrn

Cíl studie:
Vyhledat markery nedostatečné kvality endometria.

Typ studie:
Literární přehled.

Pracoviště:
Gynekologicko-porodnická klinika 1. LF UK a VFN Praha.

Výsledky:
Předkládáme přehled faktorů ovlivňujících receptivitu endometria. Data ukazují na význam exprese genů ze skupiny homeobox, zejména HOX10 a HOX 11, které zajišťují proces implantace svojí interakcí s estrogenními a progesteronovými receptory cestou stimulačních proteinů v luteální fázi. Optimální stav sliznice děložní v proliferační fázi je dán přiměřenou sekrecí osteoponinu, kadherinu, selektinu, apolipoproteinu D, mucinu a přiměřenou aktivitou makrofágů.

Závěr:
Receptivita endometria je ovlivněna expresí genů v endometriu současně s aktivitou makrofágů v nitroděložním prostředí.

Klíčová slova:
selhání implantace, receptivita endometria, exprese genů, osteoponin, integrin β3, apolipoprotein D, kadheriny, selektiny, HOX geny


Zdroje

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Štítky
Dětská gynekologie Gynekologie a porodnictví Reprodukční medicína

Článek vyšel v časopise

Česká gynekologie

Číslo 4

2014 Číslo 4

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