Cutting-edge biotechnological strategies to enhance autologous fat graft survival
Autoři:
T. Votruba 1,2; J. Holoubek 3; B. Lipovy 1
Působiště autorů:
Department of Burns Medicine, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic
1; Department of Plastic Surgery, České Budějovice Hospital, České Budějovice, Czech Republic
2; Department of Traumatology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
3
Vyšlo v časopise:
ACTA CHIRURGIAE PLASTICAE, 68, 1-2, 2026, pp. 14-18
doi:
https://doi.org/10.48095/ccachp202614
...
Zdroje
1. Limido E., Weinzierl A., Harder Y., et al. Fatter is better: boosting the vascularization of adipose tissue grafts. Tissue Eng Part B Rev. 2023, 29 (6): 605–622.
2. Acharya P., Mohammed C., Desai A., et al. Maximizing the longevity and volume retention of fat grafts: advances in clinical practice. Cureus. 2025, 17 (7): e88493.
3. Chang J., Song WJ., Soedono S., et al. Adenosine-prefabricated adipose tissue improves fat graft survival by promoting VEGF-dependent angiogenesis. Tissue Eng Regen Med. 2022, 19 (5): 1051–1061.
4. Jordao A., Cléret D., Dhayer M., et al. Engineering 3D-printed bioresorbable scaffold to improve non-vascularized fat grafting: a proof-of-concept study. Biomedicines. 2023, 11 (12): 3337.
5. Van Pham P., Vu NB., Phan NK. Hypoxia promotes adipose-derived stem cell proliferation via VEGF. Biomed Res Ther. 2016, 3 (1): 476–482.
6. Barone L., Palano MT., Gallazzi M., et al. Adipose mesenchymal stem cell-derived soluble factors, produced under hypoxic condition, efficiently support in vivo angiogenesis. Cell Death Discov. 2023, 9 (1): 174.
7. Song S., Zhang G., Chen X., et al. HIF-1a increases the osteogenic capacity of ADSCs by coupling angiogenesis and osteogenesis via the HIF-1a/VEGF/AKT/mTOR signaling pathway. J Nanobiotechnology. 2023, 21 (1): 257.
8. Teufelsbauer M., Stickler S., Eggerstorfer MT., et al. Markers for the angiogenic potential of fat grafts. Wien Klin Wochenschr. 2025, 137 (21–22): 684–692.
9. Janarthanan R., Jayakumar R., Iyer S. Injectable pectin-alginate hydrogels for improving vascularization and adipogenesis of human fat graft. J Funct Biomater. 2023, 14 (8): 409.
10. Liao HT., Marra KG., Rubin JP. Application of platelet-rich plasma and platelet-rich fibrin in fat grafting: basic science and literature review. Tissue Eng Part B Rev. 2014, 20 (4): 267–276.
11. Lu J., Li H., Zhang Z., et al. Platelet-rich plasma in the pathologic processes of tendinopathy: a review of basic science studies. Front Bioeng Biotechnol. 2023, 11 : 1187974.
12. Everts P., Onishi K., Jayaram P., et al. Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020. Int J Mol Sci. 2020, 21 (20): 7794.
13. Andia I., Maffulli N. A contemporary view of platelet-rich plasma therapies: moving toward refined clinical protocols and precise indications. Regen Med. 2018, 13 (6): 717–728.
14. Gentile P., Garcovich S. Systematic review-the potential implications of different Platelet-Rich Plasma (PRP) concentrations in regenerative medicine for tissue repair. Int J Mol Sci. 2020, 21 (16): 5702.
15. Zuleika P., Saleh I., Murti K., et al. Platelet-rich fibrin: a systematic review of its action. J Nat Sci Med. 2024, 7 (4): 242–252.
16. Zhang T., Dai J., Xu Y., et al. Liquid phase concentrated growth factor improves autologous fat graft survival in vivo in nude mice. Aesthetic Plast Surg. 2021, 45 (5): 2417 – 2422.
17. Moustaki M., Papadopoulos O., Verikokos C., et al. Application of adipose-derived stromal cells in fat grafting: basic science and literature review. Exp Ther Med. 2017, 14 (3): 2415–2423.
18. Qin Y., Ge G., Yang P., et al. An update on adipose-derived stem cells for regenerative medicine: where challenge meets opportunity. Adv Sci (Weinh). 2023, 10 (20): e2207334.
19. Toyserkani NM., Quaade ML., Sørensen JA. Cell-assisted lipotransfer: a systematic review of its efficacy. Aesth Plast Surg. 2016, 40 (2): 309–318.
20. Sutar S., Patel D., Al Ani ZM., et al. Clinical efficacy of adipose-derived stem cell-enriched lipotransfer versus conventional fat grafting: a systematic review and meta-analysis. Cureus. 2026, 18 (3): e105479.
21. Strong AL., Cederna PS., Rubin JP., et al. The current state of fat grafting: a review of harvesting, processing, and injection techniques. Plast Reconstr Surg. 2015, 136 (4): 897–912.
22. Yu F., Witman N., Yan D., et al. Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model. Stem Cell Res Ther. 2020, 11 (1): 490.
23. Han YD., Bai Y., Yan XL., et al. Co-transplantation of exosomes derived from hypoxia-preconditioned adipose mesenchymal stem cells promotes neovascularization and graft survival in fat grafting. Biochem Biophys Res Commun. 2018, 497 (1): 305–312.
24. Yang S., Sun Y., Yan C. Recent advances in the use of extracellular vesicles from adipose-derived stem cells for regenerative medical therapeutics. J Nanobiotechnology. 2024, 22 (1): 316.
25. Chen K., Xiong J., Xu S., et al. Adipose-derived stem cells exosomes improve fat graft survival by promoting prolipogenetic abilities through Wnt/b-catenin pathway. Stem Cells Int. 2022, 2022 : 5014895.
26. Wiser I., Harduf N., Tomer G., et al. Peptide hydrogel enhances adipocyte viability and reduces inflammatory response in fat grafting: a preclinical study. Aesthet Surg J Open Forum. 2026, 8: ojag045.
27. Morel SBA., Vranis N., Perez J., et al. Current applications and indications of allograft adipose matrix: a systematic review. Plast Reconstr Surg. 2026, 157 (4): 658–665.
28. Vyas KS. Discussion: current applications and indications of allograft adipose matrix: a systematic review. Plast Reconstr Surg. 2026, 157 (4): 666–669.
29. Peng Z., Tang P., Zhao L., et al. Advances in biomaterials for adipose tissue reconstruction in plastic surgery. Nanotechnol Rev. 2020, 9 (1): 385.
30. Mitsui R., Matsukawa M., Nakagawa K., et al. Efficient cell transplantation combining injectable hydrogels with control release of growth factors. Regen Ther. 2021, 18 : 372–383.
31. Kadlecová Z., Sevriugina V., Lysáková K., et al. Liposomes affect protein release and stability of ITA-modified PLGA-PEG-PLGA hydrogel carriers for controlled drug delivery. Biomacromolecules. 2024, 25 (1): 67–76.
32. Ho CK., Zheng D., Sun J., et al. LRG-1 promotes fat graft survival through the RAB31-mediated inhibition of hypoxia-induced apoptosis. J Cell Mol Med. 2022, 26 (11): 3153–3168.
33. Li Z., Lu J., Dong Z., et al. Glutathione supplementation improves fat graft survival by inhibiting ferroptosis via the SLC7A11/GPX4 axis. Stem Cell Res Ther. 2024, 15 (1): 25.
34. Sun JM., Ho CK., Gao Y., et al. Salvianolic acid B reduces the inflammation of fat grafts by inhibiting the NF-Kb signalling pathway in macrophages. Aesthet Surg J. 2023, 43 (5): NP372–NP390.
35. Amraoui N., Xu I., Robles Cortés J., et al. Improving fat graft survival using soluble molecule preconditioning. Biomolecules. 2025, 15 (4): 526.
36. Bonomi F., Limido E., Weinzierl A., et al. Preconditioning strategies for improving the outcome of fat grafting. Tissue Eng Part B Rev. 2025, 31 (2): 94–108.
37. Hasiba-Pappas S., Opriessnig E., Nischwitz SP., et al. Optimizing autologous fat grafting: a systematic review of enhancement strategies and graft survival. Aesthet Surg J. 2025: sjaf242.
Štítky
Chirurgie plastická Ortopedie Popáleninová medicína TraumatologieČlánek vyšel v časopise
Acta chirurgiae plasticae
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