Kožní ulcerace v důsledku kryoglobulinémie I. typu jako první projev mnohočetného myelomu

Skin Ulcers as a Consequence of Cryoglobulinaemia Type I - the First Symptom of Multiple Myeloma

Cryoglobulinaemia is charakterised by presence of the pathologic immunoglobulin in blood. This protein precipitates in temperature lower than 37 °C, and precipitates can raise tissue damage through the immunocomplex vasculitis. The presence of skin ulcers in affected persons is sometimes conspicuous. The patients are often treated by dermatologist or surgeon. Finding of the monoclonal immunoglobulin indicates cryoglobulinaemia type I, which is mostly associated with lymphoproliferative disease but often this possibility is not considered. This state can be influenced for a long time only by chemotherapy. We document it on the case of our patient.

Key words:
cryoglobulinaemia - skin ulcers - multiple myeloma