Kovalentní léčiva

Covalent drugs

Covalent drugs are substances capable of forming a reversible or an irreversible covalent bond with a macromolecular target in the body. Despite the risk of adverse reactions in the organism, the design of such agents has become a trend over the last two decades. Drugs acting by covalent mechanisms from different indication groups are summarized in this article and possibly supported with a reference to the crystallographic structure in the Protein Data Bank. The advantages and the disadvantages of using covalent drugs are also discussed. 

Keywords:

covalent bond – targeted covalent inhibitors