Hypertensi on therapy in obese pati ents


Authors: M. So uček
Authors‘ workplace: II. interní klinika Lékařské fakulty MU a FN u sv. Anny Brno, přednosta prof. MU Dr. Miroslav So uček, CSc.
Published in: Vnitř Lék 2009; 55(Suppl 1)(Supplementum 1): 13-18

Overview

Inter‑relati onship between hypertensi on and obesity is very well known altho ugh the actu al gro unds for this linkage are not cle ar. There is growing evidence to support the role of incre ased sympathetic nervo us system activity and involvement of the RAAS in aeti ology of hypertensi on in obese pati ents. Visceral obesity is the type of obesity we sho uld focus on in clinical practice. Tre atment of hypertensi on sho uld start with the tre atment of obesity aiming at body weight reducti on and changes to the lifestyle. Where indicated, lifestyle changes co uld, or even sho uld, be supported with an anti‑obesity agent. Positive effect of lifestyle management as well as anti‑obesity agents on blo od pressure reducti on in obese pati ents has been established. Unfortunately, informati on abo ut pharmacological management of hypertensi on in obese pati ents and its long‑term effects in particular, is lacking. Therefore, when antihypertensives are prescribed, general recommendati ons for high blo od pressure management and preventi on of cardi ovascular dise ases sho uld be followed, taking into acco unt the so far known details of pathophysi ological relati onship between high blo od pressure and obesity.

Key words:
hypertensi on –  obesity –  visceral fat –  metabolic syndrome


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