Changes to the renal function results following marathon run, a 100-kilometre run and a 24-hour long‑term run

Authors: M. Mydlík 1;  K. Derzsiová 1;  B. Bohuš 2
Authors‘ workplace: IV. interná klinika Lekárskej fakulty UPJŠ a FN L. Pasteura Košice, Slovenská republika, prednosta prof. MUDr. Ivan Tkáč, PhD., 2Klinika preventívneho a telovýchovného lekárstva Lekárskej fakulty UPJŠ a FN L. Pasteura Košice, Slovenská republika, prednost 1
Published in: Vnitř Lék 2009; 55(Suppl 1)(Supplementum 1): 103-107


Renal function assessment was conducted in 29 marathon runners, 21 runners of a 100-kilometre run and in 7 runners after 24-hour run at a stadium.

Runners’ body weight decreased in marathon runners by 1.3 ± 0.5 kg, in 100-kilometre runners by 2.4 ± 0.7 kg and in 24-hour runners by 4.4 ± 1.1 kg. Blood pressure declined after the first two runs and increased after the 24-hour run. Total proteinuria and albuminuria increased significantly after all three types of run, the least after the 24-hour long‑term run. Non-glome­rular erythrocyturia was present in the majority of runners after the marathon and 100-kilometre runs and in 2 runners only after the 24-hour run. Creatine kinase, its isoenzyme MB and myoglobin plasma levels increased significantly after all runs. Nevertheless, isoenzyme CK-MB did not exceed 6% of the total catalytic activity. These increases were due to rhabdomyolysis and were associated with myoglobinuria. Urea, creatinine and phosphorus plasma levels and FEK increased significantly after all three runs, FENa, FECl, FEOSM and FEH2O decreased. Blood pH was within the reference range during all three runs. Analysis of the base excess and standard bicarbonate after all three runs suggested mild metabolic acidosis.

The described changes to the renal function results were consequent to dehydration, protein catabolism, reduced elimination of osmotic agents, rhabdomyolysis, rennin‑angiotenzin‑aldosterone system and other factors. Renal function abnormalities in runners were absent 6–21 days after the marathon run, 100-kilometre run and 24-hour long‑term run.

Key words:
renal function result – renal stress response


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