Differences between male and female pati ents in acute cardi ac failure


Authors: J. Špinar V Zastoupení Řešitelů Studie Ahead
Authors‘ workplace: Interní kardi ologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MU Dr. Jindřich Špinar, CSc., FESC
Published in: Vnitř Lék 2009; 55(Suppl 1)(Supplementum 1): 19-22

Overview

Acute he art failure is a major and growing ca use of in hospital mortality in developed co untri es. Differences between male and female hospitalised for acute he art failure were observed in all registri es and clinical studi es. We compare data from Europe an registri es AHEAD (Acute HEArt Database), EHFS II (EuroHe art Failure Survey programme II) or DIAMOND (Dispensibility Improvement And Remodeling in Di astolic He art Failure study) with US registri es ADHERE and OPTIMIZE HF. Women are older than men when admitted with he art failure in all registri es, the me an age of women is 73– 75 ye ars, and the me an age of men is 68– 70 ye ars. Women have higher systolic blo od pressure; the me an systolic blo od pressure is abo ut 140 mm Hg for women and 130 mm Hg for men, while di astolic blo od pressure is abo ut 80 mm Hg for both sexes. He art failure with preserved left ventricular functi on predominates in women; the me an ejecti on fracti on is abo ut 43% in women, while abo ut 38% in men. Men have more frequently obstructive lung dise ase, while women have more frequently anaemi a. Despite these differences, length of stay and in‑hospital mortality rates is similar, but if adjusted for age, male gender is associ ated with an incre ased risk of de ath.

Key words:
acute he art failure –  gender differences –  age –  blo od pressure –  mortality


Sources

1. Redfi eld MM, Jacobsen SJ, Burnett jr. JC et al. Burden of systolic and di astolic ventricular dysfuncti on in the community: appreci ating the scope of the he art failure epidemic. JAMA 2003; 289: 194– 202.

2. Kitzman DW, Gardin JM, Gottdi ener JS et al. Importance of he art failure with preserved systolic functi on in pati ents > or 65 ye ars of age. CHS rese arch gro up. Cardi ovascular he alth study. Am J Cardi ol 2001; 87: 413– 419.

3. Ni eminen MS, Boehm M, Cowi e MR et al. Executive summary of the guidelines on the di agnosis and tre atment of acute he art failure. Europe an He art Jo urnal 2005; 26: 383– 416.

4. Ami odarone Tri als Meta Analysis Investigators: Effect of prophylactic ami odarone on mortality after acute myocardi al infarcti on and in congestive he art failure: meta‑analysis of individu al data from 6500 pati ents in randomised tri als. Lancet 1997; 350: 1417– 1424.

5. McCullo ugh PA, Philbin PF, Spertus JA et al. Confirmati on of he art failure epidemic: finding from the Reso urce Utilisati on Among Congestive He art Failure (REACH) study. J Am Coll Cardi ol 2002; 39: 60– 69.

6. Cleland JG, Swedberg K, Follath F et al. The EuroHe art Failure survey programme –  a survey on the qu ality of care among pati ents with he art failure in Europe. Part 1: Pati ents characteristics and di agnosis. Eur He art J 2001: 22: 228– 236.

7. Fox KF, Cowi e MR, Wo od DA et al. Coronary artery dise ase as the ca use of incident he art failure in the populati on. Eur He art J 2001; 22: 228– 236.

8. Ni eminen MS, Harjola VP, Hochadel M et al. Gender related differences in pati ents presenting with acute he art failure. Results from EuroHe art failure Survey II. Eur J He art Fail 2008; 10: 140– 148.

9. Komajda M, Follath F, Swedberg K et al. The EuroHe art failure Survey programme –  a survey of the qu ality of care among pati ents with he art failure in Europe. Part 2: Tre atment. Eur He art J 2003; 24: 464– 474.

10. Ritter M, La ule Kili an K, Klima T et al. Gender differences in acute congestive he ar failure. Swiss Med Wkly 2006; 136: 311– 317.

11. Gustafsson F, Torp- Pederse CH, Burchardt H et al. Female sex is associ ated with a better long term survival in pati ents hospitalised with congestive he art failure. Eur He art J 2004; 25: 129– 135.

12. Abraham WT, Fonarow GC, Albert NM et al. Predictors of In hospital mortality in pati ents hopizalized for he art failure. JACC 2008; 52: 347– 356.

13. Galvao M, Kalman J, Demarco T et al. Gender differences in In- Hospital Management and o utcomes in Pati ents with Decompensated He art Failure Nati onal Registry (ADHERE). J Card Fail 2006; 12: 100– 107.

14. Špinar J, Ludka O, Musil V et al. The profile and prognosis of pati ents hospitalised with he art failure. The value of discharge blo od pressure and cholesterol. Int He art J 2008; 49: 691– 705.

Labels
Diabetology Endocrinology Internal medicine

Article was published in

Internal Medicine

Issue Supplementum 1

2009 Issue Supplementum 1

Most read in this issue

This topic is also in:


Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account