Prothrombotic state in NAFLD and its consequences

Authors: A. Hvizdáková;  M. Vyskočil;  Ľ. Kekeňák;  E. Kováčová;  H. Kratochvíľová;  M. Boča
Authors‘ workplace: I. interná klinika Lekárskej fakulty UK a FNsP Bratislava, Slovenská republika, prednostka doc. MUDr. Soňa Kiňová, PhD.
Published in: Vnitř Lék 2009; 55(Suppl 1)(Supplementum 1): 94-96


Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in population. NAFLD is one part of metabolic syndrome (MS). The liver plays the role in haemostasis by the synthesis of coagulant, anticoagulant factors and haemostasis regulation. It seems recently, that there are prothrombic changes in haemostasis in patients with MS and NAFLD. They are caused by endothelial dysfunction, hypofibrinolysis and hypercoagulant state. Prothrombotic state in patients with NAFLD can by means of the insulin resis­tance increase cardiovascular risk as well as the risk of thromboembolism. The formation of microthrombi in hepatic vessels can participate also in progression of simple steatosis to steatofibrosis and liver cirrhosis.

Key words:
NAFLD – endothelial dysfunction – prothrombotic state – cardiovascular risk


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