Stereotactic body radiotherapy in the treatment of hepatocellular carcinoma

Česká verze

Authors: P. Hříbek ¹; F. Třebický ²; P. Urbánek ¹
Authors place of work: Interní klinika 1. LF UK a ÚVN – VFN Praha ¹; Ústav radiační terapie, ÚVN – VFN Praha ²
Published in the journal: Gastroent Hepatol 2025; 79(5): 356-360
Category: Přehledový článek
doi: https://doi.org/10.48095/ccgh2025356

Summary

Hepatocellular carcinoma (HCC) is one of the most serious complications of liver cirrhosis. Although early diagnosis allows for the use of curative approaches, many patients are not candidates for surgical treatment. In such cases, alternative methods of locoregional therapy gain importance. Stereotactic body radiotherapy (SBRT) is a specific form of external beam radiotherapy that enables highly precise irradiation of the target lesion with minimal impact on the surrounding tissue, achieving high rates of local disease control. Current EASL guidelines (2025) already include SBRT among recognized therapeutic options for selected patient groups, particularly when ablative techniques or TACE are not feasible. Clinical experience from our institution confirms good tolerability of SBRT and its suitability as a form of consolidative therapy. Although it remains a highly selective method with limited availability, SBRT represents a valuable complement to existing therapeutic modalities, and its role in HCC management is likely to grow in the future.

Keywords:

hepatocellular carcinoma – liver cirrhosis – radiosurgery – stereotactic body radiotherapy

Zdroje

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ORCID autorů

P. Hříbek 0000-0002-8090-4389,

F. Třebický 0000-0003-0577-9845,

P. Urbánek 0000-0002-1506-1135.

Doručeno/Submitted: 26. 6. 2025

Přijato/Accepted: 5. 8. 2025

Korespondenční autor

MUDr. Petr Hříbek, Ph.D.

Interní klinika

1. LF UK a ÚVN –⁠ VFN

U Vojenské nemocnice 1200/1

169 02 Praha 6