Angiotropic Lymphoma (Intravascular Lymphomatosis): Description of TwoCases


Authors: Z. Kinkor 1;  I. Svitáková 1;  Š. Hadravská 2;  V. Hejda 2;  M. Matějovič 3
Authors‘ workplace: Odd. patologie, FN Na Bulovce, Praha 2Šiklův ústav patologie, LF UK, Plzeň 3I. interní klinika, LF UK, Plzeň 1
Published in: Čes.-slov. Patol., , 2003, No. 1, p. 21-25
Category:

Overview

Described are two cases of angiotropic lymphoma where eventually autopsy elucidated nonspecificneurologic symptoms. One patient suffering ambiguous encephalitic syndrome died threemonths later, the second one passed away after an unusually long three -year period of progressivedementia and cumulative motoric dysfunction. The autopsy disclosed pure intravascular malignantlymphoid aggregates (LCA, CD 20, Bcl 2-positive) in the brain and kidney of both patients.In the patients with the longer disease period, a dissemination to lung was also found. Definitivediagnosis was issued as a B cell type of angiotropic lymphoma. Skin, lymph nodes, spleen, andbone marrow were not affected in any case. The clinical differential diagnosis algorithm did notinvolve this rare etiology in these particular uncommon neurologic cases and even brain biopsyperformed in both women did not recognize the substantiality of the disease.

Key words:
brain -B cell lymphoma - intravascular lymphomatosis - angiotropic lymphoma - malignantangioendotheliomatosis

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Labels
Anatomical pathology Forensic medical examiner Toxicology

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Czecho-Slovak Pathology


2003 Issue 1

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