The Aletrations in Adenosine Nucleotides andLactic Acid in Striated Muscles of Rats DuringRigor Mortis Following Death with Drowningor Cervical Dislocation

Czech version

Authors: Halime Hanim Pençe ^*; Sadrettin Pençe ^**; Naciye Kurtul ^*; Necat Yilmaz ^***; Hasan Kocoglu ^****; Ebubekir Bakan ^*
Authors‘ workplace: Atatürk University, Medical School, Department of Erzurum/Turkey **Gaziantep University, Medical School, Department of Physiology, Gaziantep/Turkey ***Gaziantep University, Medical School, Department of Biochemistry, Gaziantep/Turkey ****Gaziantep Univers ^*
Published in: Čes.-slov. Patol., , 2003, No. 1, p. 12-15
Category:

Overview

In this study, adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate(AMP) and lactic acid in the muscles of masseter, triceps, and quadriceps obtained fromright and left sides of Spraque-Dawley rats following death were investigated. The samples weretaken immediately and 120 minutes after death occurred. The rats were killed either by cervicaldislocation or drowning.ATP concentrations in the muscles of masseter, triceps, and quadriceps were lower in samplesobtained 120 minutes after death than in those obtained immediately after death. ADP, AMP, andlactic acid concentrations in these muscles were higher in samples obtained 120 minutes afterdeath than those obtained immediately after death.A positive linear correlation was determined between ATP and ADP concentrations in quadricepsmuscles of the rats killed with cervical dislocation and in triceps muscles of the rats killed withdrowning. When rats killed with cervical dislocation and with drowning were compared, ADP,AMP, and lactic acid concentrations were lower in the former than in the latter for both times(immediately and 120 minutes after death occurred). In the case of drowning, ATP is consumedfaster because of hard exercise or severe physical activity, resulting in a faster rigor mortis.Higher lactic acid levels were determined in muscles of the rats killed with drowning than theother group.In the control and electric shock rats, ATP decreased in different levels in the three differentmuscle types mentioned above in control group, being much decline in masseter and then inquadriceps. This may be caused by lower mass and less glycogen storage of masseter. No differentATP levels were measured in drowning group with respect to the muscle type possibly because ofthe severe activity of triceps and quadriceps and because of smaller mass of masseter. One canconclude that the occurrence of rigor mortis is closely related to the mode of death.

Key words:
Adenosine nucleotides – Drowning – Lactic acid – Rigor mortis

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