Tyrosine kinase inhibitors –  major change in the prognosis of chronic myeloid leukaemia

Authors: H. Klamová
Authors‘ workplace: Ústav hematologie a krevní transfuze Praha, ředitel prof. MU Dr. Marek Trněný, CSc.
Published in: Vnitř Lék 2013; 59(7): 624-626


Chronic myeloid leukaemia (CML) is an example of a tumour disease, in which the discovery of its molecular principle resulted in the development of the specific targeted molecular treatment with the first representative being imatinib. The introduction of other tyrosine kinase inhibitors, nilotinib and dasatinib, into the clinical practice meant not only a revolutionary change in the treatment approach to CML but literally an epochal improvement of the prognosis and quality of life. The disease with an originally fatal prognosis in patients dia­gnosed in the chronic stage has changed into a disease with the expected survival rate median estimated to be more than 25 years.

Key words:
chronic myeloid leukaemia –  tyrosine kinase inhibitors –  imatinib –  dasatinib –  nilotinib


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Diabetology Endocrinology Internal medicine
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