Hepatic involvement in patients with non‑Hodgkin’s lymphoma

Authors: M. Trněný 1;  J. Šálková 1;  J. Dlouhá 1;  J. Stříteský 2
Authors‘ workplace: I. interní klinika 1. lékařské fakulty UK a VFN Praha, přednosta prof. MU Dr. Marek Trněný, CSc. 1;  Ústav patologie 1. lékařské fakulty UK a VFN Praha, přednosta doc. MU Dr. Pavel Dundr, Ph. D. 2
Published in: Vnitř Lék 2013; 59(7): 606-611


Non‑ Hodgkin’s lymphoma (NHL) represent the most frequent hematological malignancy with frequent extranodal involvement. We have identified 79 pts (4.6%) out of 1,712 patients with NHL, who were dia­gnosed in our center between 1999–2010. Five cases were primary extranodal lymphomas and we have observed one primary hepatic lymphoma (0.015%). The most frequent (61.3%) NHL subtype in our cohort was diffuse large B‑ cell lymphoma. B‑ NHL formed 92.4% of all lymphomas. We have observed high number of HBsAg positive patients (10%). The whole group have poor prognostic features with high number of patients (85%) with intermediate‑ high and high risk according to international prognostic index. The patients were treated with chemotherapy in 95%, B‑ NHL patients recieved immunochemotherapy with rituximab in 77%. The median progression free survival, resp. overall survival 4.6, resp. 8.4 years in the whole group and 1.4, resp. 8.4 years in diffuse large B‑ cell lymphoma were observed with median follow-up 4.5 years. The outcome of T‑ NHL patients was significantly worse with overall survival median 1.2 vs 8.4 years (p < 0.033). The patients with B‑ NHL treated by immunochemoterapy with rituximab had significant death risk reduction (HR 0.44, p = 0.03) compared to the patients treated with chemotherapy.

Key words:
lymphoma –  non‑Hodgkin’s lymphoma –  hepatic impairment –  extranodal impairment –  immunochemotherapy –  rituximab


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