Treatment of chronic hepatitis C virus infection at the beginning of a new era


Authors: P. Urbánek
Authors‘ workplace: Interní klinika 1. lékařské fakulty UK a ÚVN Praha, přednosta prof. MU Dr. Miroslav Zavoral, Ph. D.
Published in: Vnitř Lék 2013; 59(7): 612-617
Category:

Overview

After 2010 the therapy of chronic HCV infection entered a completely new era –  the era that is marked with the gradual introduction of the so‑ called directly acting antivirals into treatment schemes of this serious disease. The term directly acting antivirals (DAA) covers low‑ molecular substances that inhibit viral non‑structural proteins –  enzymes involved in the HCV replication cycle. At present, the first 2 representatives of DAA, Boceprevir and Telaprevir, have been approved for chronic HCV infection indication. The synoptic article pays the greatest attention to these 2 representatives, along with mentioning some other substances that are under later phases of clinical development and are likely to be approved in the near future.

Key words:
chronic hepatitis C –  pegylated interferon –  ribavirin –  boceprevir –  telaprevir


Sources

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Labels
Diabetology Endocrinology Internal medicine
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