Adverse effects of NSAIDs on colopathies in older age

Authors: MUDr. Jan Trna;  Ph.D. 1;  MUDr. Oldřich Stibůrek;  Ph.D. 1;  MUDr. Ivo Novotný, CSc. 2
Authors‘ workplace: Interní gastroenterologická klinika LF MU a FN Brno 1;  Gastroenterologické oddělení Masarykův onkologický ústav 2
Published in: Geriatrie a Gerontologie 2014, 3, č. 4: 199-201
Category: Review Article


The use of nonsteroidal antiinflammatory drugs (NSAIDs) is often associated with side effects, most frequently gastrointestinal (GI) damage. Lower GI damage (including colon) is increasingly recognized in addition to the generally known upper GI damage. The use of enteric-coated and slow-release forms of NSAIDs is one of the reasons, because larger amount of the compound reaches the distal parts of GI tract. Certain types of colopathies are more prevalent in older age, which is also frequently associated with chronic NSAID abuse. This review describes the negative effect of NSAIDs on colopathies typical for older age. Both NSAID colopathy (caused directly by NSAIDs) and NSAID effect on the increased risk of diverticular bleeding and the course of microscopic colitis are discussed.

NSAID, side effect, colopathy, geriatrics, diverticulum, bleeding, microscopic colitis


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