#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Alzheimer‘s dementia – a 21th century epidemic: can we prevent it?


Authors: H. Meluzínová;  P. Weber
Authors‘ workplace: Klinika interní, geriatrie a praktického lékařstvíLF MU a FN Brno
Published in: Geriatrie a Gerontologie 2013, 2, č. 4: 192-196
Category: Review Article

Overview

The contemporary geriatric medicine endeavours to maximize the preservation of an adequate physical and mental activity, prevent the loss of self-sufficiency and improve the prognosis of the elderly in the event of illness. Therefore it has a preventive and interventional character and supports successful, healthy aging. The aim of modern geriatrics as a medical field is modified clinical management of diseases and of both health-related and social problems of seniors. This will cover the full extent of the issue of cognitive impairment and dementia in old age, or the possibility of their eventual prevention. The targets are and will be: extending the years of active life and maintaining functional capacity for as long as possible. Dementia represents a modern pandemic at the turn of the millennium, which has serious implications in biological, psychological and social terms. Due to the limited possibilities of pharmacotherapy of already developed dementia, the need of prevention is thrust to the forefront and new ways are being sought to intervene before the development of risk factors for dementia..

Keywords:
general medicine – cognitive impairment – dementia – possibilities of prevention


Sources

1. Bartošovič I: Vyšetrenie kognitívnych funkcií obyvateľov zariadení so-ciálnych služieb. Geriatria 2001; 7 (2): 80–85.

2. Middleton L, Kirkland S, Rockwood K: Prevention of CIND by physical activity: different impact on VCI-ND compared with MCI. J Neurol Sci 2008; 269 (1-2): 80–84.

3. Barnes DE, Yaffe K: The projected effect of risk factor reduction on Alzheimer‘s disease prevalence. Lancet Neurol 2011; 10 (9): 819.

4. Middleton LE, Yaffe K: Promising strategies for the prevention of dementia. Arch Neurol 2009; 66 (10): 1210–1215.

5. Akiyama H, Barger S, Barnum S et al.: Inflammation and Alzheimer‘s disease. Neurobiology of Aging 2000; 21 (3): 383–421.

6. Jessen F, Wiese B, Bickel H et al.: AgeCoDe Study Group: Prediction of dementia in primary care patients. PLoS One 2011; 6 (2): e16852.

7. Geschke K, Scheurich A, Schermuly et al.: Effectivity of early psychosocial counselling for family caregivers in general practioner based dementia care. Dtsch Med Wochenschr 2012; 137 (43): 2201–2206.

8. Kwok TC, Lam LC, Sea MM et al.: A randomized controlled trial of dietetic interventions to prevent cognitive decline in old age hostel residents. Eur J Clin Nutr 2012; 66 (10): 1135–1140.

9. Daviglus ML., Plassman BL, Pirzada A et al.: Risk factors and preventive interventions for Alzheimer disease: state of the science. Arch Neurol 2011; 68 (9): 1185.

10. Vidoni ED., Van Sciver A, Johnson DK et al.: A community-based approach to trials of aerobic exercise in aging and Alzheimer‘s disease. Contemp Clin Trials 2012; 33 (6): 1105–1116.

11. Slaughter SE, Eliasziw M, Morgan D, Drummond N: Incidence and predictors of excess isability in walking among nursing home residents with middle-stage dementia: a retrospective cohort study. Int Psychogeriatr 2011; 23 (1): 54–64.

12. Bartošovič I, Krajčík Š: Porovnanie aktivít obyvateľov domovov dôchodcov v rokoch 1989 a 2000. Čas Lék Čes 2007; 146 (7): 608–613.

13. Benito-León J, Bermejo-Pareja F, Vega S, Louis ED: Total daily sleep duration and the risk of dementia: a prospective population-based study. European Journal of Neurology 2009; 16 (9): 990–997.

14. Kröger E, Verreault R, Carmichael PH et al.: Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging. Am J Clin Nutr 2009; 90 (1): 184–192.

15. Cederholm T, Palmblad J: Are omega-3 fatty acids options for prevention and treatment of cognitive decline and dementia? Curr Opin Clin Nutr Metab Care 2010; 13 (2): 150–155.

16. Grønbaek M: The positive and negative health effects of alcohol- and the public health implications. J Intern Med 2009; 265 (4): 407–420.

17. Haag MD, Hofman A, Koudstaal PJ et al.: Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study. J Neurol Neurosurg Psychiatry 2009; 80 (1): 13–17.

18. Sparks DL, Kryscio RJ, Connor DJ et al.: Cholesterol and cognitive performance in normal controls and the influence of elective statin use after conversion to mild cognitive impairment: results in a clinical trial cohort. Neurodegener Dis 2010; 7 (1-3): 183–186.

19. Ernst E, Pittler MH: Ginkgo biloba for vascular dementia and Alzheimer’s disease: updated systematic review of double-blind, placebo-controlled, randomized trials. Perfusion 2005; 18: 388–392.

20. Herrschaft H, Nacu A, Likhachev S et al.: Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg. J Psychiatr Res 2012; 46 (6): 716–723.

21. Weinmann S, Roll S, Schwarzbach C et al.: Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr 2010; 17 (3): 10–14.

22. Annweiler C, Rolland Y, Schott AM et al.: Higher vitamin D dietary intake is associated with lower risk of alzheimer‘s disease: a 7-year follow-up. J Gerontol A Biol Sci Med Sci 2012; 67 (11): 1205–1211.

23. Etgen T, Sander D, Bickel H et al.: Vitamin D deficiency, cognitive mpairment and dementia: a systematic review and meta-analysis. Dement Geriatr Cogn Disord 2012; 33 (5): 297–305.

24. Sheardová K, Hudeček D: Prevence demence a životní styl. Neurol prax 2011; 12 (6): 403–405.

Labels
Geriatrics General practitioner for adults Orthopaedic prosthetics
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#