Prevention of venous thrombosis (phlebothromboprophylaxis) in clinical practice

Authors: P. Gavornik
Authors‘ workplace: II. interná klinika LFUK – FNsP, Bratislava, Slovenská republika ;  Prednosta: prof. MUDr. Andrej Dukát, CSc., FESC. ;  Prvé angiologické pracovisko (PAP) ;  Vedúci lekár: doc. MUDr. Peter Gavorník, PhD., mim. prof.
Published in: Prakt. Lék. 2009; 89(8): 454-457
Category: Therapy


Parenteral heparin and oral coumarin preparations represent the standard antithrombotics widely used in the prevention and treatment of venous thromboembolism (VTE). Unfractionated heparin, low molecular weight heparin, and fondaparinux have been shown to be effective and safe in reducing VTE risk. Despite high efficacy, these medicaments have limitations, which have become more apparent with the current widening of the indications for either primary thromboprophylaxis (PTP) or indefinite and even lifelong secondary thromboprophylaxis (STP). There is a need for new effective and safe medicaments with specific antithrombotic action, oral administration and convenient dosing without monitoring. During the last decade new antithrombotics have been developed either blocking selectively one coagulation enzyme or inhibiting a particular step in the coagulation cascade.

Key words:
veins, venous thromboembolism, phlebothromboprophylaxis, heparin, warfarin, new venous antithrombotics.


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