The Progress in the Treatment of Cervical Cancer – 3D Brachytherapy CT/MR-based Planning

Authors: M. Doležel 1,2;  J. Vaňásek 1;  K. Odrážka 1,2;  M. Tichý 3
Authors‘ workplace: KOC Pardubická krajská nemocnice a. s., Multiscan s. r. o. 1;  Katedra radiační onkologie IPVZ 2;  PGO Pardubická krajská nemocnice a. s. 3
Published in: Čes. Gynek.2008, 73, č. 3 s. 144-149


Brachytherapy plays a major role in the therapeutic management of patiens with cervix cancer. The rapid dose fall-off provide a very high dose to the tumor, while relative sparing bladder, rektum, sigmoid and small bowel. The CT/MR-based planning provides better information on target and organ volumes and dose-volumes histograms in contrast to radiography-based planning, that provides doses only at selected points.

Key words:
3D brachytherapy, cervical cancer, radiotherapy.


1. Barillot, I., Horiot, J., Maingon, P., et al. Maximum and mean Bladder dose defined from ultrasonography: Comparison with the ICRU reference in gynaecological brachytherapy. Radiother Oncol, 1994, 30, p. 231-238.

2. Devlin, P. Brachytherapy: Applications and techniques. Philadelphia, 2007.

3. Fellner, C., Pötter, R., Knocke, T., et al. Comparison of radiography-and computed tomography-based treatment planning in cervix cancer in brachytherapy with specific attention to some quality assurance aspects. Radiother Oncol, 2001, 58, p. 53–62.

4. Haie-Meder, C., Potter, R., Van Limbergen, E., et al. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group(I): Concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother Oncol, 2005, 74, p. 235-245.

5. Incidence nádorů v ČR 2007. Praha: ÚZIS ČR, NOR ČR, 2007.

6. International Commissionon Radiation Units and Measurements (ICRU). Dose and volume specification for reporting intracavitary therapy in gynaecology. ICRU report 38. Bethesda, 1985.

7. Lanciano, R., Martz, K., Coia, L., et al. Tumor and treatment factors improving outcome in stage III-B cervix cancer. IJROBP, 1991, 28, p. 95-100.

8. Montana, G., Fowler, W., Varia, M., et al. Carcinoma of the cervix, stage III. Results of radiation therapy. Cancer, 1986, 57, p. 148-154.

9. Pötter, R., Dimopoulos, J., Georg, P., et al. Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer. Radiother Oncol, 2007, 83, p. 148-155.

10. Pötter, R., Haie-Meder, C., Van Limbergen, E., et al. Recommendations from gynaecological (GYN) GEC ESTRO working group(II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy -3D dose volume parameters and aspects of 3D image-based anatomy, radiationphysics, radiobiology. Radiother Oncol, 2006, 78, p. 67–77.

11. Perez, C., Brady, L., Halperin, E. Principles and Practice of Radiation Oncology. 4th Ed. Philadelphia, 2004.

12. The GEC ESTRO Handbook of Brachytherapy, Ed. Gerbaulet, A., Potter, R., Mazeron, J.J., et al. 2003.

13. Shin, K., Kim, T., Cho, J., et al. CT-guded intracavitary radiotherapy for cervical cancer: Comparison of conventional Point A plan with clinical target volume-based 3D plan using dose-volume parameters. IJROBP, 2006, 64, p. 197-204.

14. Schoeppel, S., Ellis, J., LaVigne, M., et al. Magnetic rezonance imaging during intracavitary gynecologic brachytherapy. IJROBP, 1992, 23, p. 169-174.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account