Development of kidney function parameters in patients with advanced heart failure treated with levosimendan – retrospective analysis

Authors: P. Doškář 1;  F. Málek 1;  J. Dvořák 2;  P. Henyš 1;  P. Ošťádal 1;  A. Krüger 1;  D. Vondráková 1;  M. Janotka 1;  D. Říhová 1;  P. Neužil 1
Authors‘ workplace: Kardiocentrum, Nemocnice Na Homolce, Praha 1;  Státní zdravotní ústav, Praha 2
Published in: Kardiol Rev Int Med 2014, 16(1): 31-33
Category: Cardiology Review


The aim of the study was to evaluate the change of renal function parameters during hospital stay in unselected acute decompensated severe HF population treated with levosimendan.

Patient population and methods:
The change of renal parameters was assessed in 91 consecutive patients, the mean LV EF was 23%, mean urea level was 12.12 mmol/ l, mean creatinine level was 147.1 mmol/ l and estimated glomerular filtration rate (eGFR) was 42.6 ml/ min/ 1.73m2.

Mean interval between the first (V1) and the second (V2) bio­chemical evaluation was 11 days (± 7.8). Mean urea level decreased (from 12.12 to 11.37 mmol/ l, p = 0.27), as well as mean creatinine level decreased (from 147.1 to 142.5, p = 0.33), and mean eGFR increased (from 42.6 to 45.8 ml/ min/ 1.73m2, p = 0.067) in the interval between V1 and V2. Urea and creatinine levels decreased in majority of the cases (not significant) and eGFR level significantly increased in majority of the cases (68% vs 32%, p < 0.001).

Despite an insignificant change of urea and creatinine levels, the increase of eGFR was reported in majority of the cases.

advanced heart failure –  decompensation –  levosimendan –  kidney function –  glomerular filtration


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Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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