Treatment Outcome in Patients with Undifferentiated Thyroid Cancer

Authors: P. Benešová 1;  J. Astl 2;  J. Lukáš 1,2;  D. Veselý 1
Authors‘ workplace: Oddělení ORL, Oblastní nemocnice Příbram ;  primář MUDr. J. Lukáš Klinika ORL a chirurgie hlavy a krku 1. LF UK a FN Motol, Praha 1;  přednosta prof. MUDr. J. Betka, DrSc. 2
Published in: Otorinolaryng. a Foniat. /Prague/, 57, 2008, No. 2, pp. 70-73.
Category: Original Papers


Anaplastic thyroid cancer is a rare undifferentiated thyroid malignancy found in elderly patients in most cases. The authors are presenting 16 patients (female-to-male ratio was 15:1) with histologically or cytologically proven diagnosis of undifferentiated thyroid carcinoma treated during a period of 13 years (1994-2006). The age related distribution was 27-90 years. Most patients (10 from total 16) were aged 62-79 years. 12 patients underwent an operation. According to pTNM classification one case was in T4N0M0 group, 7 cases in T4N1M0 group, 3 cases in T4N1M1 group and in 5 patients the pTNM classification was not accomplished. The survival was calculated from the time of histological or cytological diagnosis and ranged from 5 days to 14 months. The largest number of patients (10 from total 16) died during a period shorter than 2 months. The mean survival in dead patients was 3.53 months. From the entire group only one female patient survived, 6 years at present. The mean survival of all patients is 7.81 months currently.

Key words:
anaplastic thyroid cancer, total thyroidectomy, radiotherapy, chemotherapy.


1. Astl, J.: Diagnostika a léčba nádorů štítné žlázy. Postgraduální medicína, 2002, s. 1016-1020.

2. Besic, N., Auersperg, M., Us-Krasovec, M., Golouh, R., Frkovic-Grazio, S., Vodnik, A.: Effect of primary treatment on survival in anaplastic thyroid carcinoma. Eur J. Surg. Oncol., 27, 2001, 3, s. 260-264.

3. Chang, H. S., Cam, K. H., Chung, W. Y., Park, C. S.: Anaplastic thyroid carcinoma: a therapeutic dilemma. Yonsei Med. J., 46, 2005, 6, s. 759-764.

4. Demeter, J. G., De Jong, S. A., Lawrence, A. M., Paloyan, E.: Anaplastic thyroid carcinoma: risk factors and outcome. Surgery, 110, 1991, 6, s. 956-963.

5. Kebebew, E., Greenspan, F. S., Clark, O. H., Woeber, K. A., McMillan, A.: Anaplastic thyroid carcinoma: Treatment outcome and prognostic factors. Cancer, 103, 2005,7, s. 1330-1335.

6. Klener, P.: Klinická onkologie. Galén, Praha, 2002, s. 555-557.

7. Pierie, J. P. E. N., Muzikansky, A., Gaz, R. D., Faquin, W. C., Ott, M. J.: The effect of surgery and radiotherapy on outcome of anaplastic thyroid carcinoma. Ann. Surg. Oncol., 9, 2002, s. 57-64.

8. Tan, R. K., Finley, R. K., Driscoll, D., Bakamjian, V., Hicks, W. L., Shedd, D. P.: Anaplastic carcinoma of the thyroid: a 24-year experience. Head Neck, 17, 1995, 1, s. 41-48.

Audiology Paediatric ENT ENT (Otorhinolaryngology)
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