Treatment Outcome in Patients with Undifferentiated Thyroid Cancer


Authors: P. Benešová 1;  J. Astl 2;  J. Lukáš 1,2;  D. Veselý 1
Authors‘ workplace: Oddělení ORL, Oblastní nemocnice Příbram ;  primář MUDr. J. Lukáš Klinika ORL a chirurgie hlavy a krku 1. LF UK a FN Motol, Praha 1;  přednosta prof. MUDr. J. Betka, DrSc. 2
Published in: Otorinolaryng. a Foniat. /Prague/, 57, 2008, No. 2, pp. 70-73.
Category: Original Papers

Overview

Anaplastic thyroid cancer is a rare undifferentiated thyroid malignancy found in elderly patients in most cases. The authors are presenting 16 patients (female-to-male ratio was 15:1) with histologically or cytologically proven diagnosis of undifferentiated thyroid carcinoma treated during a period of 13 years (1994-2006). The age related distribution was 27-90 years. Most patients (10 from total 16) were aged 62-79 years. 12 patients underwent an operation. According to pTNM classification one case was in T4N0M0 group, 7 cases in T4N1M0 group, 3 cases in T4N1M1 group and in 5 patients the pTNM classification was not accomplished. The survival was calculated from the time of histological or cytological diagnosis and ranged from 5 days to 14 months. The largest number of patients (10 from total 16) died during a period shorter than 2 months. The mean survival in dead patients was 3.53 months. From the entire group only one female patient survived, 6 years at present. The mean survival of all patients is 7.81 months currently.

Key words:
anaplastic thyroid cancer, total thyroidectomy, radiotherapy, chemotherapy.


Sources

1. Astl, J.: Diagnostika a léčba nádorů štítné žlázy. Postgraduální medicína, 2002, s. 1016-1020.

2. Besic, N., Auersperg, M., Us-Krasovec, M., Golouh, R., Frkovic-Grazio, S., Vodnik, A.: Effect of primary treatment on survival in anaplastic thyroid carcinoma. Eur J. Surg. Oncol., 27, 2001, 3, s. 260-264.

3. Chang, H. S., Cam, K. H., Chung, W. Y., Park, C. S.: Anaplastic thyroid carcinoma: a therapeutic dilemma. Yonsei Med. J., 46, 2005, 6, s. 759-764.

4. Demeter, J. G., De Jong, S. A., Lawrence, A. M., Paloyan, E.: Anaplastic thyroid carcinoma: risk factors and outcome. Surgery, 110, 1991, 6, s. 956-963.

5. Kebebew, E., Greenspan, F. S., Clark, O. H., Woeber, K. A., McMillan, A.: Anaplastic thyroid carcinoma: Treatment outcome and prognostic factors. Cancer, 103, 2005,7, s. 1330-1335.

6. Klener, P.: Klinická onkologie. Galén, Praha, 2002, s. 555-557.

7. Pierie, J. P. E. N., Muzikansky, A., Gaz, R. D., Faquin, W. C., Ott, M. J.: The effect of surgery and radiotherapy on outcome of anaplastic thyroid carcinoma. Ann. Surg. Oncol., 9, 2002, s. 57-64.

8. Tan, R. K., Finley, R. K., Driscoll, D., Bakamjian, V., Hicks, W. L., Shedd, D. P.: Anaplastic carcinoma of the thyroid: a 24-year experience. Head Neck, 17, 1995, 1, s. 41-48.

Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)
Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account