Importace of Elevation of Metallothionein Blood Levels in Patients with Head and Neck Tumors - Part 2


Authors: Z. Horáková 1;  E. Tóthová 1;  R. Salzman 1;  H. Binková 1;  I. Fabrik 2;  P. Smilek 1;  R. Kizek 2
Authors‘ workplace: Klinika otorinolaryngologie a chirurgie hlavy a krku LF MU a FN u sv. Anny, Brno ;  přednosta prof. MUDr. R. Kostřica, CSc. Ústav chemie a biochemie, Agronomická fakulta Mendelovy zemědělské a lesnické univerzity, Brno 1;  přednosta doc. RNDr. P. Hrdlička, CSc. 2
Published in: Otorinolaryng. a Foniat. /Prague/, 57, 2008, No. 2, pp. 90-97.
Category: Comprehensive Reports

Overview

Diagnostics of head and neck tumors is far from being easy and most of them are verified in advanced state. One of the reasons might be absence of a reliable diagnostic tumor marker. Authors of the following prospective study evaluated possibility of using methaleothionein as a blood tumor marker. The analysis confirmed significantly elevated level in patients with spinocelullar oropharyngeal carcinoma in comparison with a contol group. MT as diagnostic marker proved to be of a high sinsitivity a specificity. MT level didn’t correlate with any futher tumor characteristics.

Key words:
methaleothionein, oropharyngeal carcinoma, tumor marker.


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Audiology Paediatric ENT ENT (Otorhinolaryngology)
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