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The current role of radiotherapy and systemic therapy in the multidisciplinary treatment of cholangiocarcinoma

Czech version

Authors: Renata Soumarová 1;  Robert Gürlich 2;  Jan Hajer 3;  Martin Oliverius 2;  Martina Kubecová 1;  Markéta Šejdová 1;  Marián Liberko 1;  Katarína Kološtová 4
Authors‘ workplace: Radioterapeutická a onkologická klinika 3. LF UK a FN Královské Vinohrady, Praha 1;  Chirurgická klinika 3. LF UK a FN Královské Vinohrady, Praha 2;  2. interní klinika 3. LF UK a FN Královské Vinohrady, Praha 3;  Ústav laboratorní diagnostiky 3. LF UK a FN Královské Vinohrady, Praha 4
Published in: Čas. Lék. čes. 2019; 158: 78-82
Category: Review Article

Overview

Cholangiocarcinoma is a cancer with very poor prognosis. The only potentially curative approach is surgical resection of tumor. However, the rate of local and distant recurrence after radical surgery is still high. Benefit of adjuvant therapy is not clearly defined, nevertheless patients at high risk of recurrence are indicated to chemotherapy or chemoradiotherapy. Locally advanced, unresectable disease can also be treated with chemotherapy alone, or with her combination with radiotherapy. Required radiation doses are relatively high, therefore it is necessary to use highly conformal radiation therapy.

Treatment of metastatic disease is currently based on systemic therapy, combination of gemcitabine and cisplatin as standard of care. Benefit of targeted molecular therapy is not clear at present, but ongoing research in genetic profiling of tumor may help to improve current clinical practice. Patients with cholangiocarcinoma have to be discussed during multidisciplinary team meetings.

Keywords:

cholangiocarcinoma – radiotherapy adjuvant

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Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management
Epidemiology of gallbladder and bile duct malignancies in the Czech Republic
Pathology of cholangiocellular carcinoma
Molecular pathology of cholangiocellular carcinomas
The role of single-operator cholangioscopy (SpyGlass) in the intraoperative diagnosis of intraductal borders of cholangiocarcinoma proliferation – pilot study
Surgery for cholangiocarcinoma
Surveillance of chronic noninfectious diseases
Artificial intelligence and modern information and communication technologies entering medicine
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Journal of Czech Physicians

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2019 Issue 2
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