SPRINT study: far lower systolic blood pressure


Authors: prof. CSc. Mudr Miroslav Souček;  MUDr. Ph.D. Ivan Řiháček;  MUDr. Jan Novák
Authors‘ workplace: II. interní klinika LF MU a FN u sv. Anny v Brně: Pekařská 53, 656 91 Brno
Published in: Čas. Lék. čes. 2016; 155: 175-178
Category: Review Article

Overview

There is still no consensus, which blood pressure value is the most profitable for the patients when treating the systolic hypertension in the context of reduction of cardiovascular events and cardiovascular and overall mortality.

Researchers of the ACCORD study were comparing intensive treatment of systolic blood pressure bellow 120 mmHg and standard treatment reaching bellow 140 mmHg and showed no influence of intensive treatment on the primary goal in individuals with diabetes mellitus.

Last autumn, SPRINT study was presented and published showing the favourable effect of intensive (i. e. bellow 120 mmHg) blood pressure lowering on combined primary goal which was myocardial infarction, other acute coronary syndromes, ischemic stroke, heart failure or death from cardiovascular reasons. On the other hand, intensive treatment also resulted in statistically significant occurrence of adverse events (hypotension, syncope, renal injury of failure).

Keywords:
systolic blood pressure, target values, cardiovascular events, hypotension


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