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Matrix Gla protein as natural inhibitor of vascular calcification and potential treatment target


Authors: doc. MUDr. CSc. Otto Mayer jr.
Authors‘ workplace: Biomedicinské centrum LF UK Plzeň: E. Beneše ;  II. interní klinika LF UK a FN Plzeň
Published in: Čas. Lék. čes. 2016; 155: 179-182
Category: Review Article

Overview

Vascular calcification was once regarded as an advanced stage of atherosclerosis only. However, calcification is currently considered as highly regulated and potentially reversible process.

Matrix Gla protein (MGP) represents natural inhibitor of vascular calcification, whereas vitamin K is key co-factor of its maturation to the active form. There is accumulating evidence that vitamin K status and corresponding MGP activity may influence cardiovascular risk. This review summarizes pathophysiological mechanism and recent evidence relative to MGP. Moreover, available data concerning vitamin K supplementation are depicted.

Keywords:
matrix Gla protein, vitamin K, vascular calcifications, cardiovascular diseases


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