Metabolic Syndrome and Skin Diseases

Authors: Š. Svačina
Authors‘ workplace: III. interní klinika 1. LF UK a VFN, Praha
Published in: Čas. Lék. čes. 2008; 147: 307-310
Category: Review Article


Skin symptoms were originally described only in some components of the metabolic syndrome (e.g. in obesity, diabetes and polycystic ovary syndrome). In the last years several skin symptoms were described also in the metabolic syndrome. These relations were mostly described between psoriasis and metabolic syndrome, where perhaps common pathogenetic mechanisms are present. Even more important is the fact that physical activity, weight loss and diet treatment can have a common positive effect on both diseases. Also some drugs can influence both diseases together.

Key words:
diabetes mellitus, obesity, skin, psoriasis, regime treatment, pharmacotherapy.


1. Byrne, C. D., Wild, S. H. (eds.): The Metaboblic syndrome. Chichester, Wiley, 2005.

2. Svačina, Š. et al.: Metabolický syndrom. Praha, Triton, 2006.

3. Reaven, G., Laws, J.: Insulin resistance – metabolic syndrom X. New York, Humana Press, 1999.

4. Svačina, Š., Owen, K.: Syndrom inzulínové rezistence. Praha, Triton, 2003.

5. Fantuzzi, G., Mazzone, T. (eds.): Adfipose Tissue and Adipokines in Health and Disease. Humana Press, Totowa, 207.

6. Grundy, S. M.: Metabolic Syndrom. Část 1 a 2 Endocrinology and metabolism clinics of North America, svazek 33, č. 2 a 3. London, Elsevier, 2004.

7. Češka, R. et al.: Cholesterol a ateroskleróza, léčba dyslipidémií. Praha, Triton, 2005.

8. Vohradníková, O. Perušičová, J.: Kožní projevy při diabetes mellitus. Praha, Maxdorf, 2001.

9. Monami, M., Lamanna, C., Gori, F. et al.: Skin autofluorescence in type 2 diabetes, beyond blood glucose. Diabetes Res. Clin. Pract., 2008, 79, s. 56–60.

10. Mantzoros, C. S., Trakatelli, M., Gogas, H. et al.: Circulating adiponectin levels in relation to melanoma, a case-control study. Eur. J. Cancer, 2007, 43, s. 1430–1436.

11. Proksch, E.: Antilipemic drug-induced skin manifestations. Hautarzt., 1995, 46, s. 76–80.

12. Genoud, M., Wietlisbach, V., Feihl, F. et al.: Surrogate Markers for Atherosclerosis in Overweight Subjects With Atherogenic Dyslipidemia, The GEMS Project. Angiology, 2008 (e‑publikace – v tisku).

13. Pittenger, G. L., Mehrabyan, A., Simmons, K. et al.: Small fiber neuropathy is associated with the metabolic syndrome. Metab. Syndr. Relat. Disord., 2005, 3, s. 113–121.

14. Haluzík, M., Svačina, Š.: Metabolický syndrom a receptory PPAR. Praha, Grada, 2005.

15. Svačina, Š. et al.: Klinická dietologie. Praha, Grada, 2008.

16. Svačina, Š.: Metabolické receptory PPAR a kůže. Vnitř. Lek., 2006, 52, s. 451–453.

17. Gottlieb, A. B., Chao, C., Dann, F.: Psoriasis comorbidities. J. Dermatolog. Treat., 2008, 19, s. 5–21.

18. Gisondi, P., Tessari, G., Conti, A. et al.: Prevalence of metabolic syndrome in patients with psoriasis, a hospital-based case-control study. Br. J. Dermatol., 2007, 157, s. 68–73.

19. Cohen, A. D., Sherf, M., Vidavsky, L. et al.: Association between psoriasis and the metabolic syndrome. A cross-sectional study. Dermatology, 2008, 216, s. 152–155.

20. Neimann, A. L., Shin, D. B., Wang, X. et al.: Prevalence of cardiovascular risk factors in patients with psoriasis. J. Am. Acad. Dermatol., 2006, 55, s. 829–835.

21. Sommer, D. M., Jenisch, S., Suchan, M. et al.: Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis. Arch. Dermatol. Res., 2006, 298, s. 321–328.

22. Karamfilov, T., Elsner, P.: Sports as a risk factor and therapeutic principle in dermatology. Hautarzt., 2002, 53, s. 98–103.

23. Wolters, M.: Diet and psoriasis, experimental data and clinical evidence. Br. J. Dermatol., 2005, 153, s. 706–714.

24. Svačina, Š.: Metabolické účinky psychofarmak. Praha, Triton, 2004.

25. Buckingham, R. E.: Thiazolidinediones, Pleiotropic drugs with potent anti-inflammatory properties for tissue protection. Hepatol Res., 2005, 33, s. 167–170.

26. Marra, M., Campanati, A., Testa, R. et al.: Effect of etanercept on insulin sensitivity in nine patients with psoriasis. Int. J. Immunopathol. Pharmacol., 2007, 20, s. 731–736.

27. de Menezes-Ettinger, J. E., Azaro, E., de Souza, C. A. et al.: Remission of psoriasis after open gastric bypass. Obes. Surg., 2006, 16, s. 94–97.

28. Setty, A. R., Curhan, G., Choi, H. K.: Obesity, waist circumference, weight change, and the risk of psoriasis in women, Nurses‘ Health Study II. Arch. Intern. Med., 2007, 167, s. 1670–1675.

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management fenix.admin.empty
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account