Apolipoprotein AV and Triglyceridemia


Authors: J. A. Hubáček
Authors‘ workplace: Centrum experimentálního výzkumu chorob srdce a cév – IKEM, Praha
Published in: Čas. Lék. čes. 2004; : 799-803
Category:

Overview

High plasma triglyceride levels have been suggested to be independent risk factors of cardiovascular diseasedevelopment and cardiovascular diseases are the most common cause of death in industrial countries around theworld. It is known, that plasma levels of triglycerides are partially genetically determined. The importance of apoAVgene for determination of plasma triglyceride levels has been suggested by creations of transgenic and knock-outmice and confirmed on population studies. More then ten variants have been described in the human apoAV gene.Associations between four of them (T-1131→C, Ser19→Trp,Val153→Met a Cys185→Gly) and plasma triglyceridelevels have been intensively analysed in different populations.Althoughwith some differences between ethnic groups,alleles C-1131, Trp19 a Cys185 (so far detected just in Chinese population) are connected with elevated levels ofplasma triglycerides. First analysis have detected that T-1131→C a Ser19→Trp apoAV variants could influence riskof myocardial infarction and size of LDL particles. Val153→Met polymorphism is not associated with plasma levelsof triglycerides, but females homozygous for Val153 have elevated levels of plasma HDL cholesterol.

Key words:
apolipoprotein AV, triglycerides, myocardial infarction, polymorphism.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management fenix.admin.empty
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