Resistance of Mycobacterium Tuberculosis on Antituberculotic Drugs inCzech Republic in 2003

Authors: J. Homolka;  F. Krejbich;  M. Havelková 1
Authors‘ workplace: I. klinika tuberkulózy a respiračních nemocí 1. LF UK a VFN, Praha 1Státní zdravotní ústav, Praha
Published in: Čas. Lék. čes. 2004; : 836-839


The results of Mycobacterium tuberculosis susceptibility testing in 2003 were analysed in 568 (84 %)pulmonary TB definite cases in the Czech Republic.Methods and Results. The resistance on antituberculotic drugs was detected in 4,9% of TB bacilli.Most frequently,resistance on one drug – isoniazid (1,8 % of pulmonary TB definite cases) has been observed. Multidrug resistantTB was found in two cases in 2003.Conclusions. The resistance of Mycobacteria was found significantly more often in foreign-born persons withpulmonary TB (25% of strains of TB bacilli were resistant on one or more AT drugs). Resistance on AT drugs wasmore frequent also in previously treated TB cases, especially if the relapse occurred after 3,5 years after finishingprevious treatment.

Key words:
tuberculosis, Mycobacterium tuberculosis, epidemiology, resistance, MDR TB.

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