Sepsis – how to recognize and what to focus on – back to basics in the light of the new definition

Authors: Jan Horák 1,2;  Martin Harazim 1;  Thomas Karvunidis 1,2;  Jaroslav Raděj 1,2;  Ivan Novák 1;  Martin Matějovič 1,2
Authors‘ workplace: I. interní klinika LF UK a FN Plzeň 1;  Biomedicínské centrum LF UK, Plzeň 2
Published in: Vnitř Lék 2016; 62(7-8): 568-574
Category: Reviews


Sepsis is the primary cause of death from infection. However, its early recognition remains a fundamental challenge in clinical practice. In February 2016, a newly revised sepsis definition has been published (SEPSIS-3). Sepsis has been redefined as life-threatening organ dysfunction caused by a dysregulated host response to infection. In this article, we introduce the updated definition of sepsis, discuss its pros and cons and suggest practical implications. The emphasis is put on basic and comprehensive clinical assessment.

Key words:
definition – early recognition of sepsis – infection – sepsis – septic shock


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