Clinical significance of natriuretic peptides in the differential diagnosis of dyspnea

Authors: Jiří Špác
Authors‘ workplace: II. interní klinika LF MU a FN U sv. Anny v Brně
Published in: Vnitř Lék 2016; 62(7-8): 640-645
Category: Reviews

Biomarkers make bad doctors worse and good doctors better | Biomarkery dělají ze špatných lékařů horší a z dobrých lékařů lepší.
Maisel A, přednáška ESC 2011


Acute dyspnea is one of the most common emergency department symptoms. But early diagnosis and treatment could be e challenging because of multiple potential causes. The gold standard biomarkers in cardiac dyspnea are B-type natriuretic peptide (BNP) and N-terminal pro-B-type (natriuretic peptide NT-pro BNP), which play an important role in the diagnosis, prognosis, and management of acute decompensated heart failure. The purpose of this review is to analyze diagnostic potential of BNP and NT-pro BNP biomarkers use in patients with acute dyspnea. BNP and NT-proBNP are markers of cardiac stress but are not cardiac-specific. They have comparable clinical utility, and both help in excluding acute cardiac dyspnea but they cannot reliably discriminate systolic from diastolic HF.

Key word:
acute dyspnea – natriuretic peptide – heart failure


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