Granulomatosis with polyangiitis manifested as diabetes insipidus

Czech version

Authors: Ondřej Pátek ¹; Miroslava Horáčková ¹; Lenka Vítová ¹; Rudolf Horváth ²; Jaromír Háček ³; Otto Schück ¹
Authors‘ workplace: Interní klinika 2. LF UK a FN v Motole, Praha ¹; Oddělení revmatologie dětí a dospělých FN v Motole, Praha ²; Ústav patologie a molekulární medicíny 2. LF UK a FN v Motole, Praha ³
Published in: Vnitř Lék 2016; 62(7-8): 679-683
Category: Case Reports

Overview

The case report shows a surprising presentation of pulmonary granulomatosis with polyangiitis (GPA) through symptoms of diabetes insipidus (DI) with granulomatous infiltration of the pituitary gland. The pituitary hormonal dysfunction as a result of granulomatosis of the pituitary gland is rare. Several studies have demonstrated that the incidence of the pituitary dysfunction reaches approx. 1 % of the patients with GPA. However it is mostly presented in patients with the disease already diagnosed. The patient described by us had no clinical expressions of GPA in the respiratory tract. He presented with polyuria and polydipsia. It was not until a more detailed examination of these symptoms was performed that a focal lung disease was detected and diagnosed as GPA.

Key words:
diabetes insipidus – granulomatosis with polyangiitis – granulomatous infiltration of the pituitary gland – pituitary hormonal dysfunction

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