Prevention and therapy of sarcopenia in the ageing

Authors: Zdeněk Zadák
Authors‘ workplace: Centrum pro výzkum a vývoj III. interní gerontometabolické kliniky LF UK FN Hradec Králové
Published in: Vnitř Lék 2016; 62(7-8): 671-677
Category: Reviews


Sarcopenia is one of the severe disorders associated with nutritional imbalance. While sarcopenia is an inseparable part of the process of ageing as people get older, it plays a vital role in pathological situations such as protein-calorie and kwashiorkor malnutrition, it accompanies various diseases of rheumatic character and is an almost ever-present feature of the clinical picture of oncological patients. Sarcopenia in people under strain is fatally manifested mainly in the elderly, medically fragile patients. In view of the fact that sarcopenia is the decisive factor regarding the course of chronic as well as acute illnesses, it must be diagnosed, monitored and appropriately treated in time. Although nutrition is not the only factor involved especially in older age in the development of sarcopenia, the type of nutritional support and, in the new era, particularly nutritional pharmacology, form the underlying principles of the approach to the comprehensive care of the patient.

Key words:
ageing – lipids – malnutrition – proteosynthesis – sarcopenia


1. Zadák Z. Výživa v intenzivní péči. 2.ed. Grada: Praha 2008. ISBN 978–80–247–2844–5.

2. Zadák Z, Havel E et al. Intenzivní medicína na principech vnitřního lékařství. Grada: Praha 2007. ISBN 978–80–247–2099–9.

3. Bahat G, Ilhan B. Sarcopenia and the cardiometabolic syndrome: A narrative review. Eur Geriatr Med 2016; 7(3): 220–223.

4. Thomas DR. Loss of skeletal muscle mass in aging: Examining the relationship of starvation, sarcopenia and cachexia. Clin Nutr 2007; 26(4): 389–399.

5. Batsis JA, Mackenzie TA, Jones JD et al. Sarcopenia, sarcopenic obesity and inflammation: Results from the 1999–2004 National Health and Nutrition Examination Survey. Clin Nutr 2016; pii: S0261–5614(16)30020–6. Dostupné z DOI: <>.

6. Acharyya S, Butchbach MER, Sahenk Z et al. Dystrophin glycoprotein complex dysfunction: A regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell 2005; 8(5): 421–432.

7. Arik G, Ulger Z. Vitamin D in sarcopenia: Understanding its role in pathogenesis, prevention and treatment. Eur Geriatr Med 2016; 7(3): 207–213.

8. Zadák Z, Květina J. Metodologie předklinického a klinického výzkumu v metabolismu, výživě, imunologii a farmakologii. Galén: Praha 2011. ISBN 978–80–7262–748–6.

9. Kalinkovich A, Livshits G. Sarcopenia – The search for emerging biomarkers. Ageing Res Rev 2015; 22: 58–71.

10. Chen JL, Walton KL, Winbanks CE et al. Elevated expression of activins promotes muscle wasting and cachexia. FASEB J 2014; 28(4): 1711–1723.

11. Boström PA, Fernández-Real JM, Mantzoros C. Irisin in humans: recent advances and questions for future research. Metabolism 2014; 63(2): 178–180.

12. Sergi G, Trevisan C, Veronese N et al. Imaging of sarcopenia. Eur J Radiol 2016; 85(8): 1519–1524.

13. Lardiés-Sánchez B, Sanz-Paris A, Boj-Carceller D et al. Systematic review: Prevalence of sarcopenia in ageing people using bioelectrical impedance analysis to assess muscle mass. Eur Geriatr Med 2016; 7(3): 256–261.

14. Kim JS, Wilson JM, Lee SR. Dietary implications on mechanisms of sarcopenia: roles of protein, amino acids and antioxidants. J Nutr Biochem 2010; 21(1): 1–13.

15. Song YH, Song JL, Delafontaine P et al. The therapeutic potential of IGF-I in skeletal muscle repair. Trends Endocrinol Metab 2013; 24(6): 310–319.

16. Nissen SL, Abumrad NN. Nutritional role of the leucine metabolite β-hydroxy β-methylbutyrate (HMB). J Nutr Biochem 1997; 8(6): 300–311.

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